Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [5]

2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global...

SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), and regulating energy metabolism (11, 12) and the senescence-associated secretory phenotype (SASP) (13, 14).

SIRT6, a member of the Sirtuin family of NAD + -dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and …

2025年2月8日 · SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. SIRT6 is upregulated in both paclitaxel-resistant and epirubicin-resistant MCF-7 cells. SIRT6 plays a role in regulating the terminal effector pathways of human labor and delivery via the NFKB pathway.

Sirt6 is one such gene that not only regulates DNA repair, but also maintains epigenomic stability and promotes longevity. Specifically, SIRT6 promotes base excision repair (Mostoslavsky et al., 2006) and both the homologous recombination (HR) and the non-homologous end joining (NHEJ) pathways of DSB repair (Mao et al., 2011; Toiber et al., 2013).

Sirtuin 6 (Sirt6), a mammalian Sir2 (silent information regulator-2) ortholog, is an NAD+-dependent histone deacetylase that modulates chromatin structure and genomic stability. Sirt6 knockout cells demonstrate genomic instability, and a deficiency ...

2021年5月28日 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in vivo multi-omics analyses...

2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and...

2016年11月8日 · SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and cancer, and can promote longevity in mice.

The biological functions of SIRT6 (e.g. deacetylation, defatty-acylation and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric ...

2021年4月21日 · The nuclear localized protein deacetylase, SIRT6, has been identified as a crucial regulator of biological processes that drive aging. Among these processes, SIRT6 can promote resistance to oxidative stress conditions, but the precise mechanisms remain unclear.

2022年4月5日 · SIRT6 is a member of the Sir2-like family in mammals. Recent structural and biochemical studies have characterized SIRT6 as having deacetylation, defatty-acylation, and mono-ADP-ribosylation activities, which determine its important regulatory roles during physiological and pathological processes.

2021年6月1日 · Khan et al. show that SIRT6, a nuclear sirtuin, regulates the transcription of fatty acid transporter genes in the heart through the PPARγ transcription factor in a deacetylase-independent manner. Notably, deficiency of SIRT6 causes increased fatty acid uptake and lipid accumulation in the heart.

Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in hepatic lipid homeostasis and liver health.

The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty-acylation, and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance.

2024年12月21日 · Here, we show that protein deacetylase SIRT6 was down-regulated in BLCA, and predicts poor overall survival. SIRT6 deficiency notably enhances BLCA cell proliferation, self-renewal, and migration capacities in vitro and in vivo. Mechanistically, SIRT6 interacts with, deacetylates, and promotes UHRF1 degradation mediated by β-TrCP1.

2021年7月17日 · Sirtuin 6 (SIRT6) extends mammalian lifespan and promotes healthspan. SIRT6 maintains genomic stability through improved efficiency of DNA repair. SIRT6 maintains heterochromatin and silences repetitive genetic elements. Regulation of SIRT6 is a potential strategy for rejuvenation.

2023年5月16日 · Longevity focused biotech SIRTLab emerges from stealth, aiming for first human trials of SIRT6-boosting therapeutic in 2024. Last week, US-Israeli startup SIRTLab announced the appointment of leading geroscience researcher Nir Barzilai as its Chief Medical Adviser.

A Schematic of genomic DNA region around exon 2 and exon 3 of Sirt6 in mice.B, C The appearance of the skull at E13.5 and EdU staining of E13.5 palatal tissues, Bar: 50 μm, PS palatal shelves, n = 6.D Alizarin red and Alcian blue staining skeletons of E17.5 Control and Sirt6 cKO mice. Note ossification of palatine bone in Control and Sirt6 cKO mice (black arrows).