Sirtuin 5 - Wikipedia
Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the …
SIRT5 Gene - GeneCards | SIR5 Protein | SIR5 Antibody
2024年12月25日 · SIRT5 (Sirtuin 5) is a Protein Coding gene. Diseases associated with SIRT5 include Urea Cycle Disorder and Hypertrophic Cardiomyopathy. Among its related pathways …
SIRT5: a potential target for discovering bioactive natural products ...
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant …
SIRT5 Regulates Energy Metabolism and Survival in Acute …
2023年11月2日 · SIRT5 is a lysine deacylase that regulates multiple metabolic pathways, including energy metabolism. We have previously reported that a subset of acute myeloid …
SIRT5 induces autophagy and alleviates myocardial infarction via ...
2024年8月30日 · Recent studies have highlighted the potential role of SIRT5 in various human diseases, including MIRI. This study aims to investigate the specific role of SIRT5 in …
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation ...
2025年1月28日 · SIRT5 stands out due to its defined role in mitochondrial function and its dependence on NAD+, distinguishing it from potential non-sirtuin desuccinylases that might …
Sirt5 preserves cardiac function in ischemia-reperfusion injury by ...
2024年11月26日 · Here we report a cardioprotective role of the mitochondrial protein Sirt5 in a mouse model of cardiac IR injury. The down-regulation of Sirt5 in IR-injured heart is …
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 …
2023年3月9日 · SIRT5 controls a wide range of aspects of myocardial energy metabolism and plays critical roles in heart physiology and stress responses. Moreover, SIRT5 has a protective …
药物发现 | 蛋白质赖氨酸脱酰基酶Sirtuin 5（SIRT5）的治疗潜力和 …
Sirtiun 5（SIRT5）是一种 NAD+ 依赖性的蛋白质赖氨酸脱酰基酶，主要位于 线粒体 中。 SIRT5对带负电荷的酰基显示出亲和力，主要催化赖氨酸脱谷氨酰化、脱琥珀酰化和脱丙醇酰化，同时 …
Sirtuins in kidney diseases: potential mechanism and therapeutic ...
2024年2月12日 · Sirt5. Sirt5 exhibits a strong affinity for negatively charged acyl groups, such as glutaric, succinic, and malonic acids; catalyses mainly lysine acylation, but also desuccinylates …