NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)].

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses ...

2024年12月25日 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and …

2020年7月9日 · Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs.

2012年5月15日 · SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic acid cycle, fatty acid β-oxidation and …

SIRT3 alleviates liver diseases by regulating fatty acid metabolism, mitochondrial function, and immune-inflammatory response. Meanwhile, Withaferin A, lipoic acid, major royal jelly proteins, and berberine can activate SIRT3 or upregulate its expression, thereby alleviating liver damage.

2024年6月25日 · Citrate synthase (CS) is activated by SIRT3, promoting the condensation of acetyl-CoA with oxaloacetate to form citrate. SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) causing conversion of isocitrate to α-ketoglutarate, a crucial step that helps maintain the flow of the TCA cycle.

SIRT3 is a mitochondrial sirtuin deacetylase that activates mitochondria functions and plays an important role in metabolism, oxidative stress, and cell survival (Giralt and Villarroya, 2012; Weir et al., 2013), and SIRT3 may also ameliorate disease states. Thus, SIRT3 could be a promising target for novel therapies. Brenna Osborne, ...

SIRT3 influences oxidative phosphorylation and oxidative stress management. SIRT3 increases ETC efficiency by deacetylating and regulating the activities of mitochondrial complexes I, II, III, IV and V to increase ATP production.

2024年5月15日 · Herein, we identified a new small-molecule activator of SIRT3 (named 2-APQC) by the structure-based drug designing strategy. 2-APQC was shown to alleviate isoproterenol (ISO)-induced cardiac...