Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids.

2024年12月25日 · SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a Protein Coding gene. Diseases associated with SGK1 include Gastric Cancer and Hematologic Cancer. Among its related pathways are Gene expression (Transcription) and Regulation of …

2024年12月5日 · Conclusions: These findings highlight the key role of SGK1 in the pathogenesis of TAD. A lack of SGK1 inhibits VSMC phenotypic transformation by regulating the SIRT6-MMP9 axis, providing insights into potential epigenetic strategies for TAD treatment.

2024年2月1日 · Serum and glucocorticoid-regulated kinase 1 (SGK1) is a ubiquitously expressed protein belonging to the Ser/Thr kinase family. It regulates diverse physiological processes, including epithelial sodium channel activity, hypertension, cell proliferation, and insulin sensitivity.

Results suggest that SGK-1 is an injury-responsive kinase that could mediate mechanical stretch-induced proliferation of vascular cells in vein graft, leading to neointima formation.

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a member of the protein kinase A, G, and C (AGC) family (Firestone et al., 2003). SGK1 was first identified in rat mammary gland tumor cells in response to serum/glucocorticoid stimulation, and its expression has been detected in all tissues (Webster et al., 1993).

SGK-1 has been shown to be strongly involved in mechanisms associated with homeostasis of body fluid and then with the hypertension by regulating different kidney channels. Moreover, SGK-1 is involved in neurodegeneration by inactivating FOXO3a and decreasing neuronal apoptosis and hyperexcitability by controlling gene expression of Kv channels.

2021年1月19日 · SGK1 is considered a canonical factor affecting the expression and signal transduction of multiple genes involved in the genesis and development of many human cancers. Abnormal expression of SGK1 has been found in tissue and may hopefully become a useful indicator of cancer progression.

血清和糖皮质激素诱导蛋白激酶 (SGKs)是一种AGC家族的丝氨酸苏氨酸蛋白激酶,其包括位于不同染色体的三个基因编码的蛋白激酶 (SGK1,SGK2,SGK3). SGKs主要由磷脂酰肌醇-3-激酶 ( PI3K)激活,通过磷酸化下游的靶蛋白调控细胞的生长,神经元兴奋性,肾钠排泄等. SGK1作为PI3K通路主要的调节靶点,不仅参与离子转运,T细胞活化,炎症抑制,脂肪细胞分化,还在心肌细胞纤维化,血管钙化,炎症性肠病,自噬抑制,结直肠癌及多形胶质母细胞瘤等多种临床生理和病理过程中起重要作用.

血清/糖皮质激素调节激酶 1： 该基因编码在细胞应激反应中起重要作用的丝氨酸/苏氨酸蛋白激酶。 这种激酶激活某些钾、钠和氯通道，表明参与细胞存活、神经元兴奋性和肾钠排泄等过程的调节。