Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including enterocytes, the liver and adrenal gland. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver.

2024年12月25日 · SCARB1 (Scavenger Receptor Class B Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 and Hypoalphalipoproteinemia, Primary, 1.

2023年8月29日 · Scavenger receptor class B type I, also known as SCARB1 or CLA-1 (CD-36 and LIMPII analog 1), is a membrane protein with a molecular weight of 82 kDa that acts as the major HDL receptor and...

2021年5月12日 · SCARB1 polymorphisms are associated with elevated high density lipoprotein-associated cholesterol, dyslipidemia, and CAD, and genetic deletion of Scarb1 accelerates atherosclerosis in mice. However, this report is the first to demonstrate the influence of inherited SCARB1 variants on human disease.

Scavenger receptor B type 1 (SR-B1) is a cell surface HDL receptor that mediates HDL-CE uptake. It is most abundantly expressed in liver, where it provides cholesterol for bile acid synthesis, and in steroidogenic tissues, where it delivers cholesterol needed for storage or steroidogenesis in rodents.

2025年2月8日 · SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp(a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a).

2016年9月20日 · Human SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp (a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via …

Mechanistically, SCARB1 inhibits ferroptosis through the regulation of cholesterol metabolism, and the upregulation of CoQ10 level is demonstrated to mediate the suppression of ferroptosis by SCARB1 after lipidomic analysis and metabolic intervention.

SR-B1 belongs to the class B scavenger receptor, or CD36 super family. SR-B1 and CD36 share an affinity for a wide array of ligands. Although they exhibit similar ligand binding specificity, SR-B1 and CD36 have some very specific lipid transport functions.

2021年7月2日 · Dr. Koenig’s work reveals the first causative relationship between SCARB1 variants and the presentation of severe, early-onset CAD. Further, her findings open doors in the exploration of HDL metabolism as a therapeutic target for dyslipidemia and ASCVD.