2024年12月25日 · S1PR1 (Sphingosine-1-Phosphate Receptor 1) is a Protein Coding gene. Diseases associated with S1PR1 include Central Nervous System Angiosarcoma and …

Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular …

2021年12月22日 · Sphingosine-1-phosphate receptor 1 (S1PR1) is a master regulator of lymphocyte egress from the lymph node and an established drug target for multiple sclerosis …

Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play an important role in the immune system. …

S1PR1-Associated Molecular Signature Predicts Survival in Patients with Sepsis. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent …

Here, we outline the structure and function of S1PR1, highlighting the key residues involved in receptor activation, signaling, transmembrane interactions, ligand binding, post-translational …

2022年5月4日 · Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Sphingosine 1-phosphate (S1P) and S1P receptors (S1PR) regulate migration of lymphocytes out of thymus to blood and lymph nodes (LN) to efferent lymph, while their role in other tissue sites …

Our study identifies S1P-S1PR1-nitric oxide signaling as a new regulatory pathway in vivo of vascular relaxation to flow and BP homeostasis, providing a novel therapeutic target for the …

2022年6月29日 · Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play an important role in the …