2024年12月25日 · RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Granulomatosis With Polyangiitis and Vasculitis. Among its related pathways are NR1H2 and NR1H3-mediated signaling and Gene expression (Transcription).

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene. [5][6] This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA).

该基因编码视黄酸 X 受体 (RXR) 核受体家族的成员，这些核受体参与介导视黄酸 (RA) 的作用。 编码的蛋白质与视黄酸、甲状腺激素和维生素 D 受体形成同源二聚体，从而增加它们各自反应元件的 DNA 结合和转录功能。 该基因位于 6 号染色体上的主要组织相容性复合体 (MHC) II 类区域中。 已经观察到该基因编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2012 年 7 月]

2023年8月18日 · RXR（Retinoid X receptor）是核受体家族的重要成员，其主要作用机制是通过形成同源二聚体或异源二聚体，调控靶基因表达。 同时，RXR出核后，可通过磷酸化、截短等修饰，调控细胞凋亡、有丝分裂等活动。 因此，RXR的失调可能从核内、核外调控两个方面共同导致肿瘤的发生和发展。 本文综述了RXR在肿瘤发生过程中的潜在机制，归纳了具有抗瘤作用的重要RXR靶向调控分子（图1）。 图1 RXR信号通路与肿瘤发生. 随着科学家对癌基因及相关突变 …

Gene ID: 6257, updated on 8-Feb-2025. This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA).

2021年3月2日 · RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest. Title: Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade. A fatty acid-binding protein 7/RXRbeta pathway enhances …

2019年3月1日 · RXRA promotes cell cycle arrest, dopaminergic phenotype and neuritogenesis. RXRA restrains ERK1/2 overactivation. RXRB inhibits neuritogenesis. Retinoic acid (RA) promotes differentiation in multiple neurogenic cell types by promoting gene reprogramming through retinoid receptors and also by inducing cytosolic signaling events.

2023年11月23日 · Clinical resource with information about RXRB, Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Retinoic acid receptor RXR-beta is a protein in humans that is encoded by RXRB gene. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.

Enables nuclear receptor activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in regulation of myelination. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human RXRB (retinoid X receptor beta).