2024年12月25日 · RPP21 (Ribonuclease P/MRP Subunit P21) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and tRNA processing. Gene Ontology (GO) annotations related to this gene include ribonuclease P activity.

Intron retention and splice-site selection in Rpp21 precursor mRNA regulate the intranuclear distribution of the protein products and their association with the RNase P holoenzyme.

Rpp21 and Rpp29 are promptly recruited to laser-induced and γ-irradiated DSBs and are vital to the subsequent homology-directed repair, but not non-homologous end joining. H1 RNA is implicated in the recruitment of Rpp21 and Rpp29 to the damaged sites ( Abu-Zhayia et al. 2017 ).

Intron retention and splice-site selection in Rpp21 precursor mRNA regulate the intranuclear distribution of the protein products and their association with the RNase P holoenzyme. Our study reveals that dynamic nuclear structures that include nucleoli, the perinucleolar compartment and Cajal bodies are all involved in the production and ...

The catalytic asset of human RNase P is related to the H1 RNA subunit. Rpp29 and Rpp21 serve as cofactors for H1 RNA with which these two subunits form an active RNP complex 34, 38, 66, 67. In this study, we have shown that Rpp29, Rpp21 and H1 RNA are involved in DDR.

2025年2月8日 · RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

2025年1月4日 · Gene target information for RPP21 - ribonuclease P/MRP subunit p21 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2025年1月4日 · RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009] Genomic context

FUNCTION: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor.

an essential subunit of Saccharomyces cerevisiaenuclear RNase P. Rpp21 is encoded by a gene that resides in the class I gene cluster of the major histocompatibility complex, is associated with highly purified RNase P, and binds precursor tRNA. Rpp21 is predominantly localized in the nucleoplasm but is also observed in nucleoli and Cajal