Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2 or retinaldehyde dehydrogenase 2 (RALDH2), is an enzyme that in humans is encoded by the ALDH1A2 gene. [5][6] ALDH1a2 belongs to the aldehyde dehydrogenase family …

2024年12月24日 · ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2) is a Protein Coding gene. Diseases associated with ALDH1A2 include Diaphragmatic Hernia 4, With Cardiovascular Defects and Renal Hypodysplasia/Aplasia 1. Among its related pathways are Signaling by Retinoic Acid and ESR-mediated signaling.

2002年11月26日 · Knockout of the murine retinoic acid (RA)-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2) gene leads to early morphogenetic defects and embryonic lethality.

The enzyme retinal dehydrogenase type-2 (RALDH2) catalyzes much of the retinoic acid formation during development, but not all. RALDH2 is crucial for development midgestation and helps drive neural, heart, lung, and forelimb development; it is also responsible for all retinoic acid development during certain periods of midgestation. [ 22 ]

In the present study, we investigated the role of the enzyme retinaldehyde dehydrogenase 2 (RALDH2) which catalyzes RA synthesizes by initiating meiosis in chicken ovarian germ cells.

2025年2月8日 · Raldh2 and Cyp26 generate shifting boundaries of retionic acid activity, controlling hindbrain segmental gene expression. RALDH2 plays a crucial role in producing RA (retinoic acid) required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm.

RALDH2 is expressed in the chick choroid and is modulated by the visual environment. RALDH2 expression correlates with changes in all-trans-retinoic acid synthesis and is likely responsible for scleral proteoglycan synthesis inhibition during ...

We found that mouse Aldh1 and Raldh2 both stimulate both stimulate RA synthesis when expressed in Xenopus embryos, with Raldh2 being more efficient than Aldh1. The distinct localization patterns of ALDH1 and RALDH2 proteins in mouse embryos and adult tissues suggest that these two RA synthetic enzymes initially establish differential cranial ...

We show that the retinaldehyde dehydrogenase 2 (RALDH2) enzyme is responsible for RA synthesis in the mouse craniofacial region and forebrain between the 8- and 15-somite stages. Raldh2-/- knockout embryos exhibit defective morphogenesis of various forebrain derivatives, including the ventral diencephalon, the optic and telencephalic vesicles.

2015年1月5日 · This study reports loss of RA synthesis in Raldh2-knockout mice, providing the first demonstration that RA is essential for early organogenesis in mouse embryos.