2005年6月1日 · Rab5 is one of the more intensely studied members of the large and diverse family of Rab GTPases 1. Functional studies indicate that it is a key regulator of early endocytosis, where it is...

2020年2月11日 · Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes.

2004年8月24日 · Here we discovered a novel PI (3)P-binding Rab5 effector, Rabankyrin-5, which localises to early endosomes and stimulates their fusion activity. In addition to early endosomes, however, Rabankyrin-5 localises to large vacuolar structures that correspond to macropinosomes in epithelial cells and fibroblasts.

2020年9月23日 · 小GTP酶 (small GTPase) Rab5/RAB-5定位于早期内吞体，募集效应因子以调控包括内吞循环运输在内的多类型生物学过程[1-3]，例如Rab5效应蛋白Rabenosyn-5与Rab4、膜塑性…

2007年7月2日 · Perturbation of endocytosis by other means did not affect ER structure; the role of RAB-5 in ER morphology is thus independent of its well-studied requirement for endocytosis. RAB-5 and YOP-1/RET-1 also control the kinetics of nuclear envelope disassembly, which suggests an important role for the morphology of the peripheral ER in this process.

2024年12月25日 · RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5B include Amyotrophic Lateral Sclerosis 1 and Cardiofaciocutaneous Syndrome. Among its related pathways are Infectious disease and Rab regulation of trafficking. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding.

2005年5月15日 · Consistent with the known catalytic function of Vps9 domains in Rab5 GDP/GTP exchange, we found that RME-6 binds specifically to Caenorhabditis elegans RAB-5 in the GDP-bound conformation, and...

RAB-5 promotes C. elegans embryonic polarity in both dynamin-dependent and -independent manners, by controlling PAR-6 localization. RAB-5 and RAB-11 are required for plasma membrane repair after attack by bacterial pore-forming toxin. Data suggest that TBC-2 functions on RAB-7-positive late endosomes to inactivate RAB-5 during endosome maturation.

Here we show instead that endocytosis is dispensable and post-Golgi vesicle transport is crucial for the formation of endosomes and the subsequent endolysosomal traffic regulated by yeast …

RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes. [7] . It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles. [8] RAB5A has been shown to interact with: