Therapeutic advances in the targeting of ROR1 in hematological …
Malignant cells use ROR1 expression to promote survival, proliferation and migration, processes normally active in embryonic cells, but redirected by cancer cells to support tumor growth and …
Analysis of ROR1 Protein Expression in Human Cancer and …
2017年6月15日 · ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression, and multiple groups are developing antibodies and/or chimeric antigen …
ROR1 Gene - GeneCards | ROR1 Protein | ROR1 Antibody
2024年12月25日 · ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare …
Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid …
2021年10月12日 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate …
ASH: MSD’s ROR1 drug hits the target in first-line lymphoma
5 天之前 · MSD starts pivotal trial of ROR1 drug in first-line lymphoma. MSD has started a phase 3 trial of ROR1-directed ADC zilo-V as a treatment for previously untreated diffuse large B-cell …
Novel humanized monoclonal antibodies against ROR1 for cancer …
2024年8月13日 · Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor …
Receptor tyrosine kinase-like orphan receptor 1: A novel ... - PubMed
2024年5月24日 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and …
Immunome Doses First Patient in Phase 1 Trial of IM-1021, a ROR1 ...
2025年3月10日 · IM-1021 is an optimized, ROR1-targeted ADC that incorporates Immunome’s proprietary TOP1 inhibitor, HC74. The Phase 1 trial is an open-label, multicenter dose …
ROR1: an orphan becomes apparent | Blood - American Society of …
2022年10月6日 · Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has …
A Phase 1/2 Study of a ROR1-Targeting CAR T Cell Therapy …
2024年11月5日 · ROR1 is an oncoembryonic pseudo-tyrosine kinase receptor expressed on malignant cells across a variety of hematologic and solid malignancies. As such, ROR1 is an …
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