The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review focuses on human ...

Ribonuclease P (RNase P) is an ancient and essential endonuclease that catalyses the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). The enzyme is one of only two ribozymes which can be found in all kingdoms of life (Bacteria, ...

RNase P is an endo-ribonuclease required for processing precursor tRNA into mature tRNA. RNase P is a highly conserved ribonucleoprotein composed of (i) an RNA ribozyme that catalyzes RNA hydrolysis, and (ii) species-specific protein subunits.

2006年10月1日 · Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the maturation of the 5′ end of transfer RNA (tRNA).

RNase P is responsible for generating the mature 5′-end of tRNAs by a single endonucleolytic cleavage of their precursors. It is an essential, ubiquitous enzyme present in all cells and cellular compartments that synthesize tRNA: bacterial cells, eukaryotic nuclei, …

2024年2月12日 · RNase P is recruited to DNA DSBs and represses H3.3 recruitment to actively transcribed genes. RPP21 and RPP29 are recruited to DNA DSBs by binding to PAR moieties, while H1 RNA may provide a potential platform for the …

Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5’ end maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes have been identified and studied throughout the three domains of life. ...

2022年6月18日 · Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.

We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity.

2024年5月9日 · Ribonuclease P (RNase P) was first described in the 1970's as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components.