一、RNF8，全称 ring finger protein 8，是近年发现的一种 DNA损伤应答 蛋白。它包含 485 个氨基酸残基， 在人体组织中广泛表达， 是一种含有 FHA 及 RING 结构域的 E3 泛素连接酶 。

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. [5][6][7] RNF8 has activity both in immune system functions [8] and in DNA repair. The protein …

2024年12月25日 · RNF8 (Ring Finger Protein 8) is a Protein Coding gene. Diseases associated with RNF8 include Riddle Syndrome and Xeroderma Pigmentosum, Variant Type. Among its …

RNF8 is the human orthologue of the yeast protein Dma1p; RNF8 is a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and …

该基因编码的蛋白质包含一个无名指基序和一个 FHA 结构域。 这种蛋白质已被证明与几种 II 类泛素结合酶 (E2) 相互作用，包括 UBE2E1/UBCH6、UBE2E2 和 UBE2E3，并且可以在某些核 …

2012年1月22日 · Nature Structural & Molecular Biology - RNF8 and RNF168 are E3 ligases that promote the ubiquitination of histones at sites of double-strand breaks. Now RNF8 is shown to …

2007年11月30日 · RNF8 is a key player involved in the crosstalk between different protein modifications, with its FHA domain required for its localization to DNA-damage foci through a …

During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. Showing features for mutagenesis, natural variant. …

2025年3月7日 · The ubiquitination of histone H2A/H2AX, catalyzed by RNF8/RNF168, is a crucial step in the repair of DNA double-strand breaks (DSBs), playing a significant role in transmitting …

RNF8 is a key ubiquitin regulator in the DDR pathway. RNF8 translocates to DSBs via phospho-MDC1 and recruits BRCA1 and 53BP1 by ubiquitination of histone proteins and DDR-related …