2024年12月25日 · RGS4 (Regulator Of G Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include Bipolar Disorder and Schizophrenia. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding.

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling. [5] Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. [6] .

RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis. Targeting RGS4 Ablates Glioblastoma Proliferation. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.

2021年6月25日 · Drawing on pharmacological and rescue experiments in MZrgs4, we provide evidence that Rgs4 facilitates signaling mediated by Akt, Erk and mTOR in order to drive axon outgrowth in motoneurons and...

2024年9月11日 · rgs4蛋白是g蛋白信号调控中的关键负调控因子，通过促进gα亚基的gtp水解来限制gpcr信号的持续性和强度。 它在神 经系统和心血管系统中发挥着重要作用，其功能异常与多种疾病相关，包括神经障碍和心血管疾病。

Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits. Rgs4 is expressed in several brain ...

Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia ...

g 蛋白信号调节器 4 蛋白与 rgs1 的同一性为 37%，与大鼠 rgs4 的同一性为 97%。该蛋白在异源三聚体 g 蛋白的上游或水平负向调节信号传导，并定位于细胞质中。

2020年6月9日 · RGS2 and RGS4 forms ternary complex with PAR4 in Gα-dependent manner and inhibits its downstream signaling. Our findings support a novel physiological function of RGS2 and RGS4 as inhibitors of PAR4-mediated signaling through selective PAR4/RGS/Gα coupling.

2020年10月10日 · 人们已经单独评估了一些RGS蛋白，但在这项新的研究中，Martemyanov及其同事们煞费苦心地分析了在人类细胞中发现的所有20种RGS蛋白，研究每一种蛋白如何选择性地识别和调节对应的G蛋白。 在这样做的过程中，这些研究人员基本上为GPCR信号如何在细胞中构建路径绘制了路线图。 论文第一作者、Martemyanov实验室研究员Ikuo Masuho博士说，“这种对G蛋白亚基的选择性识别原来是由每个RGS蛋白中的几个序列元件来执行的--这些序列元件以类似 …