
Retinoblastoma protein - Wikipedia
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One …
RB1 Gene - GeneCards | RB Protein | RB Antibody
2024年12月25日 · RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Small Cell Cancer Of The Lung. Among its …
RB1 : governor of the cell cycle in health and disease-a ... - PubMed
2024年6月19日 · RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the …
Pan-cancer molecular analysis of the RB tumor suppressor …
2020年4月2日 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and …
RB1 gene - MedlinePlus
Hundreds of mutations in the RB1 gene have been identified in people with retinoblastoma, a rare type of eye cancer that typically affects young children. This cancer develops in the retina, …
The retinoblastoma tumor-suppressor gene, the exception that …
2006年8月28日 · Hereditary retinoblastoma is caused by germline transmission of one mutationally inactivated Rb1 allele and loss of the remaining wild-type allele in somatic retinal …
RB1 RB transcriptional corepressor 1 [ Homo sapiens (human) ]
2025年3月4日 · Title: Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance. Retinoblastoma-associated protein is important for TRIM24-mediated activation of …
RB1, development, and cancer - PubMed
The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research since …
Cell cycle and beyond: Exploiting new RB1 controlled mechanisms …
Canonically, RB1 regulates cell cycle progression and represents the down-stream target for CDK4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1 …
RB1 RB transcriptional corepressor 1 - NIH Genetic Testing …
2025年1月4日 · Clinical resource with information about RB1, Bone osteosarcoma, Malignant tumor of urinary bladder, Retinoblastoma, Small cell lung carcinoma, and available tests. …