The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a …

2024年12月25日 · RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Small Cell Cancer Of The Lung. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

2024年6月19日 · RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distin …

2020年4月2日 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and therapeutic responses.

Hundreds of mutations in the RB1 gene have been identified in people with retinoblastoma, a rare type of eye cancer that typically affects young children. This cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.

2006年8月28日 · Hereditary retinoblastoma is caused by germline transmission of one mutationally inactivated Rb1 allele and loss of the remaining wild-type allele in somatic retinal cells.

2025年3月4日 · Title: Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance. Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.

The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research since its discovery has not only illuminated a general role for RB1 in …

Canonically, RB1 regulates cell cycle progression and represents the down-stream target for CDK4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1-pathway suggest new therapeutic strategies to counter resistance and improve precision medicine.

2025年1月4日 · Clinical resource with information about RB1, Bone osteosarcoma, Malignant tumor of urinary bladder, Retinoblastoma, Small cell lung carcinoma, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.