PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions, PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in fibroblasts. Disruption of PU.1 in fibrotic fibroblasts leads to them returning into their resting state from pro-fibrotic fibroblasts.

PU.1表达在粒细胞和巨噬细胞分化过程中增加，而在T淋巴细胞和B淋巴细胞分化过程中降低。 本研究回顾并讨论了转录因子PU.1对免疫细胞分化的影响。 转录因子PU.1是ETS家族的重要成员，在免疫细胞的分化中起着重要作用，免疫细胞包括巨噬细胞，嗜中性粒细胞，树突状细胞，T淋巴样细胞，B淋巴样细胞等。 免疫细胞参与疾病的发生和发展，包括炎性疾病，赘生性疾病和免疫疾病。 因此，阐明PU.1在免疫细胞中的作用和机制尤为关键。 对这些机制的阐明可能导致开 …

2010年6月3日 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein–protein interactions with ...

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.

Ets 转录因子 PU.1 对于诱导胎儿肝脏和成人骨髓中的单核细胞、巨噬细胞和 B 细胞的分化至关重要。 PU.1 通过与其他转录因子（例如 C/EBPα 和 AP-1 家族成员 c-Jun）的物理相互作用来控制造血分化。我们发现 PU.1 将 c-Jun 招募到没有 AP-1 结合位点的启动子上。

2020年1月21日 · Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing...

2020年10月21日 · PU.1 regulates gene expression in early T cells positively and negatively via two distinct mechanisms: It not only opens chromatin and nucleates with transcriptional co-factors, such as Satb1 and Runx1 at its binding sites to form cooperative complexes, but also competitively redistributes its co-factors, often removing them from sites where ...

We found that conditional ablation of the Ets-family transcription factor PU.1 in DC-restricted progenitors led to increased pDC production at the expense of cDCs. PU.1 controlled many of the cardinal functions of DCs, such as antigen presentation by cDCs and …

1999年4月1日 · PU.1 controls important genes required for the normal maturation and differentiation of B cells (e.g. immunoglobulins, MB1) and macrophages (M-CSF receptor), that are involved in maturation, differentiation and proliferation. PU.1 is not required in neutrophil differentiation but functional abnormalities appear when PU.1 is lacking.

PU.1是ETS转录因子家族(E26 transformation-specific family)的成员,在机体多种组织发育中发挥重要作用.近年来的研究发现,PU.1不仅在造血谱系的确定和分化中起作用,而且还在机体免疫,脂肪形成,组织纤维化,神经发育中发挥功能.在造血及免疫等系统中,PU.1与多个靶基因形成 ...