2024年12月25日 · PTGES3 (Prostaglandin E Synthase 3) is a Protein Coding gene. Diseases associated with PTGES3 include Primary Hypertrophic Osteoarthropathy and Autism Spectrum Disorder. Among its related pathways are Fatty acid metabolism and Infectious disease.

Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. [5] The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning of the glucocorticoid and other steroid receptors. [6]

2025年2月9日 · PTGES3 is a Putative Prognostic Marker in Breast Cancer. A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome.

Prostaglandin E Synthase 3 (PTGES3) is a putative prognostic marker in many solid tumors; however, its expression and biological functions in HCC have not been determined. The proteolysis-targeting chimera (PROTAC) is an established technology for …

Prostaglandin E synthase enzyme 3 (PTGES3), also known as p23, is an oncogene mediating the expression of prostaglandin E2 (PGE2), which promotes tumor growth through multifactorial mechanisms such as upregulating anti-apoptotic genes (2).

2024年1月20日 · PTGES3 knockdown significantly inhibited BC cell proliferation and migration. Three drugs (gedunin, genistein and diethylstilbestrol) were confirmed to target PTGES3, and genistein and diethylstilbestrol demonstrated stronger binding affinities than did gedunin.

The PTGES3 gene was not associated with disease-free survival of PDAC patients (Figure 2F). Based on tissue expression and survival analysis, only the PTGES gene was significantly increased in pancreatic cancer patients and associated with worse prognosis of patients.

PTGES3 is the most highly expressed enzymes within the COX/PG pathway in both luminal and basal epithelial cells in normal breast tissues. Using Cox Regression Kaplan-Meier survival analysis, PTGES3 expression had a significant inverse prognostic association with breast cancer survival [HR >1.43, P = 0.0057].

PTGES3 may play an important role in the cell cycle and as an independent predictive prognostic biomarker correlates with immune infiltrates in lung adenocarcinoma.

2024年1月20日 · PTGES3 was found to be a novel drug target in a robust six-gene prognostic signature that may serve as a potential therapeutic strategy for BC. Breast cancer (BC) is the most common malignancy in women and one of the three most common cancers worldwide, along with lung and colon cancer [1, 2, 3].