2024年12月25日 · PSME4 (Proteasome Activator Subunit 4) is a Protein Coding gene. Diseases associated with PSME4 include Angelman Syndrome and Congenital Disorder Of Deglycosylation 1. Among its related pathways are Metabolism of proteins and Autodegradation of …

Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene. [5] [6] [7]

2023年5月22日 · Through profiling of the degradation landscape of patient-derived non-small-cell lung carcinoma samples, we find that the proteasome regulator PSME4 is upregulated in tumors, alters proteasome...

Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

2025年2月9日 · The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC. Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing. The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.

2022年8月20日 · Here, we will discuss the structure, biology, and function of the alternative Proteasome Activator 200 (PA200), also known as PSME4, and summarize the current evidence for its dysregulation in different human diseases.

2023年5月23日 · Through profiling of the degradation landscape of patient-derived non-small-cell lung carcinoma samples, we find that the proteasome regulator PSME4 is upregulated in tumors, alters proteasome activity, attenuates presented antigenic diversity and associates with lack of response to immunotherapy.

PSME4-001: 7099: 1843aa: ENSP00000384211.1 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. CCDS33197: Q14997: NM_014614.2: A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

2022年3月29日 · 临床MM患者GEO数据集分析结果显示，在MM患者细胞中，I3MO作用靶点PSME3和PSME4均过度表达，其表达水平与MM细胞的复发耐药性相关。Kaplan-Meier分析显示，PSME3或PSME4高水平表达的患者生存期显著缩短，患者预后差。

Functional annotation of a full-length mouse cDNA collection. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.