The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. [5] This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity.

2024年12月25日 · PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PRKACA include Pigmented Nodular Adrenocortical Disease, Primary, 4 and Cardioacrofacial Dysplasia 1.

PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.

蛋白激酶 A 对蛋白质的 cAMP 依赖性磷酸化对许多细胞过程很重要，包括分化、增殖和凋亡。 由体细胞突变或包括该基因的区域的基因组重复引起的该基因的组成性激活与肾上腺皮质的增生和腺瘤有关，并且与促肾上腺皮质激素非依赖性库欣综合征有关。 可变剪接导致编码不同异构体的多个转录变体。 已经描述了 N 末端不同的组织特异性亚型，并且这些亚型可能在某些亚型的 N 末端发生的翻译后修饰不同。 [RefSeq 提供，2015 年 1 月]

2024年4月15日 · 山西医科大学Ji-Min Cao/De-Ping Wang教授团队在本刊发表了题为“Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway”的研究快讯，揭示了Kcr在结直肠癌中的关键作用。这些发现为结直肠癌的早期发现和创新治疗策略提供了新的 ...

PRKACA，cAMP-dependent protein kinase catalytic subunit alpha,别名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A（PKA）的α催化亚基，PKA是一种由cAMP激活的丝氨酸/苏氨酸蛋白激酶，由两个催化亚基和两个调节亚基组成。在没有cAMP时，PKA以钝化复合体形式存在。

2015年5月20日 · In this review, we summarize the current understanding of the involvement of PRKACA in adrenocortical tumorigenesis, and our understanding of PKA's role in adrenocortical lesions. We also discuss potential therapeutic advances that can be made through targeting of PRKACA and the PKA pathway.

2016年2月15日 · This article focuses on the discovery, structure, cellular location and physiological effects of the catalytic subunit alpha of protein kinase A (encoded by the gene PRKACA). We also explore the potential role of this essential gene as a molecular mediator of certain disease states.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

2024年9月19日 · This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.