Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. [5][6] This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. [7] .

2024年12月25日 · PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Methylmalonic Acidemia. Among its related pathways are Nuclear events mediated by NFE2L2 and Gene expression (Transcription).

Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine -induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6.

Variants (also known as mutations) in the PRDX1 gene are involved in methylmalonic acidemia with homocystinuria, epi-cblC type (shortened to epi-cblC), which is one form of a disorder that causes developmental delay, eye defects, neurological problems, and blood abnormalities.

In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its ...

Prdx1 deficiency increases macrophage foam cells in atherosclerotic plaques. To elucidate whether the impaired lipophagic flux caused by oxidative stress in Prdx1-deficient macrophages affects macrophage function, we first examined the lipoprotein uptake ability of macrophages.

Prdx1 prevents Akt-driven tumorigenesis through protecting PTEN lipid phosphatase activity from oxidation-induced inactivation. (A) Prdx1 regulates PTEN phosphatase activity during oxidative stress, since binding of Prdx1 and PTEN occurs in conditions of mild or nil cellular stress.

Prdx1 is the host factors required for efficient transcription and replication of measles virus. PRDX1 was associated with the cyclooxygenase (COX)-2 upstream promoter region at sites occupied by NF-kappaB in ER- but not in ER+ breast cancer cells.

2024年9月19日 · Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. PRDX1 gene-related epi-cblC disease is a common type of inborn error of cobalamin metabolism with mono- or bi-allelic MMACHC epimutations.

2024年1月1日 · PRDX1 plays a dual role as both peroxidase and molecular chaperone. PRDX1 can be both tumour promotor and suppressor. PRDX1 inhibitors has proved antitumour efficacy in various cancer types. New technologies contribute to the development of PRDX1 inhibitors.

2024年3月1日 · One of the identified proteins is PRDX1, also known as peroxiredoxin 1, which is a 23-kDa redox protein found in macrophages that is generated by stress and exhibits many activities. PRDX1 expression is correlated with reactive ROS …

2013年1月21日 · Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H 2 O 2 -scavenging function, mediates cell signaling through redox-specific protein–protein interactions. Our data...

2022年11月3日 · PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 also reduces intramolecular cystine bridges (summary by Yan et …

2021年8月13日 · Peroxiredoxin 1 (PRDX1) belongs to an abundant family of peroxidases whose role in cancer is still unresolved. While mouse knockout studies demonstrate a tumour suppressive role for PRDX1, in...

2016年9月21日 · PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1-regulated ROS-dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers.

This study reveals that PRDX1 is crucial to regulating lipophagic flux and maintaining macrophage cholesterol homeostasis against oxidative stress. We suggest that PRDX1-dependent control of oxidative stress may provide a strategy for treating atherosclerosis and …

PRDX1, which belongs to the PRDX family, is composed of thiol-specific antioxidant enzymes that reduce H 2 O 2 and peroxynitrite [40, 41] and is associated with mitigation of oxidative damage [42]. PRDX1 has been proved to be overexpressed in breast cancer [43], malignant mesothelioma [44] and lung cancer [45].

2022年8月1日 · Prdx1 (Peroxiredoxin-1) deficiency exacerbates ischemic brain damage and microglia cell death. Prdx1 -dependent antioxidant pathways are required for both activating SAM and restricting oxidative stress. Ischemic stroke is the leading cause of immortal disability and death worldwide.

2016年5月4日 · We documented the early time course evolution of circulatory Prdx1, hypoxic marker carbonic anhydrase IX, inflammatory cytokines including IL-6, IL-8, IL-10, MCP-1, TNF-α, IL-1β, and danger signaling receptors (TLR4 and CD14) in a cohort of cardiogenic shock patients within 1 day after ECMO support.