2007年12月6日 · Here, we show that proteins fused to the human cytomegalovirus tegument protein pp65 were bound with higher efficiency to DCs than those fused to the described PTDs …

Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser536 of human NF-κB p65. Transcription factors of …

Functional genomics revealed a role for the major cytomegalovirus structural protein, pp65 (ppUL83), in counteracting this response. The underlying mechanism involves a differential …

To comprehensively analyze CD8 + T cell responses against the CMV pp65 antigen restricted by a single HLA class I allotype, we conducted ELISPOT assays using an artificial antigen …

Here we describe a pp65‐derived peptide (pp65 340–355, RQYDPVAALFFFDIDL: RQY16‐mer), characterized by peculiar features. First, RQY‐16mer is able to stimulate HCMV pp65 specific …

2012年1月17日 · Pp65 is the most abundant tegument protein and the major constituent of extracellular virus particles . However, pp65 is not essential for the production of new …

2020年6月15日 · Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes. J Med Virol 43, 103–110 (1994).

This article focuses on HCMV tegument pp65 by reviewing its mechanisms of action in favoring virus evasion from the host innate immune response. Keywords: Antiviral defense; DNA …

2016年1月18日 · The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity and T-cell receptor usage of pp65 …

2023年8月18日 · Data indicate that cytomegalovirus pp65-specific T cells lyse autologous, primary glioblastoma (GBM) tumor cells in an antigen-specific manner. The results are …