2024年12月25日 · PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include Sebaceous Adenocarcinoma and Meibomian Cyst. Among its related pathways are …

2022年5月25日 · Here, we show that Plin2-mediated moderate lipid hydrolysis is critical for pluripotency of embryonic stem cells (ESCs). Upon exit from pluripotency, lipid droplet (LD) …

Mechanistically, it is demonstrated that PLIN2 boosts HIF1α/SPP1 signaling in macrophages, thereby exerting pro-tumor functions. Finally, a PLIN2-targeting liposome is designed to …

Although perilipin 2 (Plin2) has been shown to bind lipids with high affinity, the Plin2 lipid binding site has yet to be defined. This is of interest since Plin2’s affinity for lipids has been suggested …

2017年7月3日 · Here we show that PLIN2 overexpression protects lipid droplets against macroautophagy/autophagy, whereas PLIN2 deficiency enhances autophagy and depletes …

2019年5月6日 · In this study, we hypothesized that deficiency in Plin2 would result in reduced myocardial lipid storage. In contrast to our hypothesis, we found increased accumulation of …

2023年7月25日 · Here, we performed a series of parallel CRISPR-Cas9 loss-of-function screens in a set of genome-edited PLIN2 reporter cells. These screens provide a phenotype-rich …

2025年2月9日 · PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. Bildirici I, et al. Endocrinology, 2018 Dec 1. PMID 30351430, Free PMC …

2023年5月8日 · Our findings reveal the critical regulation of PLIN2 -induced ectopic lipid accumulation in phase-related muscle ageing plasticity. We initially determined the lifespan …

Here we show that PLIN2 overexpression protects lipid droplets against macroautophagy/autophagy, whereas PLIN2 deficiency enhances autophagy and depletes …