
PLD1 Gene - GeneCards | PLD1 Protein | PLD1 Antibody
2024年12月25日 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways are Glycerophospholipid biosynthesis and Signaling by Rho GTPases.
磷脂酶 D1(PLD1)基因 | MCE - MCE-生物活性分子大师
该基因编码磷脂酰胆碱特异性磷脂酶,该酶催化磷脂酰胆碱的水解以产生磷脂酸和胆碱。 该酶可能在信号转导和亚细胞运输中发挥作用。 可变剪接导致具有催化和调节特性的多个转录变体。 [RefSeq 提供,2011 年 9 月] This gene encodes a phosphatidylcholine-specific Phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to …
Phospholipase D信号通路signaling pathway-武汉华美生物
PLD信号通路是细胞内的一种次级信号传递系统,通过PLD代谢产物——PA的作用,参与调控多种生物学过程,包括细胞分化、增殖、运动、内质网应激反应以及膜结构、细胞架构的改变等。 研究表明,PLD在多种疾病的发生和发展中也具有重要作用,如癌症、心血管疾病、神经系统疾病等。 因此,对于PLD信号通路的研究和调控也具有非常重要的生态和医学意义。 磷脂酶D信号通路涉及多个细胞过程,例如细胞内蛋白运输,细胞骨架组织,细胞增殖,细胞存活,甘油脂代谢和肿 …
PLD1 is a key player in cancer stemness and chemoresistance ...
As PLD1 is a novel target of vorinostat resistance, combination therapy with PLD1 inhibitors and vorinostat may represent a potential therapeutic strategy against GBM tumorigenesis. PLD1‐based TMZ resistance mechanisms in GSCs represent crucial …
Phospholipase D1 - Wikipedia
Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5][6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7] The possibility of PLD1 was first mentioned in 1947 by authors Hanahan and Chaikoff at Berkeley when describing a carrot enzyme that could " [split] choline from phospholipids." [8]
PLD1 phospholipase D1 [Homo sapiens (human)] - Gene - NCBI
2025年1月4日 · Title: PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
5337 - Gene ResultPLD1 phospholipase D1 [ (human)]
PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism; PLD1 may play a crucial role in collagen type I production through mTOR signaling in human dermal fibroblast. phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells
研究揭示真核生物磷脂酶D的结构与机制 - 中国科学院
2019年10月18日 · 10 月 16 日, Cell research 在线发表了中国科学院分子植物科学卓越创新中心张鹏研究组题为 Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D 的研究论文。 该研究解析了植物磷脂酶 Dα1 及其与产物磷脂酸 (PA) 复合体的晶体结构,详细阐释了真核生物磷脂酶 D 催化磷脂产生磷脂酸及其活性调节的分子机制。 磷脂酶(Phospholipase, PL)催化细胞膜上磷脂的水解。 根据水解部分的不同,人们将磷脂 …
PHOSPHOLIPASE D1, PHOSPHATIDYLCHOLINE-SPECIFIC; PLD1
2017年5月16日 · Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis.
PLD1 is a key player in cancer stemness and chemoresistance
2024年7月1日 · PLD1 inhibition specifically targets GSCs but not neuroprogenitor cells. PLD1 depletion sensitizes GSCs to the effect of TMZ on GSC‐derived intracranial tumors 17.