2024年12月25日 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways are Glycerophospholipid biosynthesis and Signaling by Rho GTPases.

该基因编码磷脂酰胆碱特异性磷脂酶，该酶催化磷脂酰胆碱的水解以产生磷脂酸和胆碱。 该酶可能在信号转导和亚细胞运输中发挥作用。 可变剪接导致具有催化和调节特性的多个转录变体。 [RefSeq 提供，2011 年 9 月] This gene encodes a phosphatidylcholine-specific Phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to …

PLD信号通路是细胞内的一种次级信号传递系统，通过PLD代谢产物——PA的作用，参与调控多种生物学过程，包括细胞分化、增殖、运动、内质网应激反应以及膜结构、细胞架构的改变等。 研究表明，PLD在多种疾病的发生和发展中也具有重要作用，如癌症、心血管疾病、神经系统疾病等。 因此，对于PLD信号通路的研究和调控也具有非常重要的生态和医学意义。 磷脂酶D信号通路涉及多个细胞过程，例如细胞内蛋白运输，细胞骨架组织，细胞增殖，细胞存活，甘油脂代谢和肿 …

As PLD1 is a novel target of vorinostat resistance, combination therapy with PLD1 inhibitors and vorinostat may represent a potential therapeutic strategy against GBM tumorigenesis. PLD1‐based TMZ resistance mechanisms in GSCs represent crucial …

Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5][6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7] The possibility of PLD1 was first mentioned in 1947 by authors Hanahan and Chaikoff at Berkeley when describing a carrot enzyme that could " [split] choline from phospholipids." [8]

2025年1月4日 · Title: PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.

PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism; PLD1 may play a crucial role in collagen type I production through mTOR signaling in human dermal fibroblast. phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells

2019年10月18日 · 10 月 16 日， Cell research 在线发表了中国科学院分子植物科学卓越创新中心张鹏研究组题为 Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D 的研究论文。 该研究解析了植物磷脂酶 Dα1 及其与产物磷脂酸 (PA) 复合体的晶体结构，详细阐释了真核生物磷脂酶 D 催化磷脂产生磷脂酸及其活性调节的分子机制。 磷脂酶（Phospholipase, PL）催化细胞膜上磷脂的水解。 根据水解部分的不同，人们将磷脂 …

2017年5月16日 · Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis.

2024年7月1日 · PLD1 inhibition specifically targets GSCs but not neuroprogenitor cells. PLD1 depletion sensitizes GSCs to the effect of TMZ on GSC‐derived intracranial tumors 17.