Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of ...
Using neutrophils from mice deficient in Phd3, we demonstrated a unique role for Phd3 in prolonging neutrophil survival during hypoxia, distinct from other hypoxia-associated changes …
脯氨酸羟化酶研究进展 - tougao120.com
phd3可增加m2型丙酮酸激酶(pkm2)和hif-1α的联系，激活多个结构域，包括hif-1α的反式激活结构域和pas结构域，pkm2激活hif的靶基因，在癌细胞中使得糖酵解增多 [24] 。所以，phd在hif依 …
Cell | 肥胖抑制T细胞功能，代谢干预可改善肿瘤免疫疗法 - 知乎
phd3是 脯氨酰羟化酶 家族的成员，可通过调节转录因子 hif1α 来调节与炎症和免疫控制中的许多信号通路，此外也发现phd3通过抑制长链脂肪酸进入线粒体来调节脂肪酸氧化（fao），结果 …
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic ... - PubMed
We examined PHD expression in human neutrophils and found that PHD3 was strongly induced in response to hypoxia and inflammatory stimuli in vitro and in vivo. Using neutrophils from …
Role and regulation of prolyl hydroxylase domain proteins
2008年2月15日 · Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)- α subunits by prolyl hydroxylase domain (PHD) proteins signals their polyubiquitination and proteasomal …
癌症中PHD3的丢失通过ACC2的失活使代谢依赖于脂肪酸氧 …
我们发现，PHD3表达在包括急性髓细胞性白血病（AML）在内的癌症子集中大大降低，并且与脂肪分解代谢的依赖性有关，而与外部营养因素无关。 PHD3的过表达通过调节ACC2限制 …
Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in ...
5 天之前 · A significant reduction in Sirt1 and Phd3 expression, along with an increase in Hif-1α and cleaved caspase-3, was observed in a time-dependent manner post-myocardial infarction …
Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein …
The HIF prolyl hydroxylases (PHDs/EGLNs) are central regulators of the molecular responses to oxygen availability. One isoform, PHD3, is expressed in response to hypoxia and causes …
PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in …
2020年8月4日 · PHD3-null mice demonstrate loss of ACC2 hydroxylation in heart and skeletal muscle and display elevated fatty acid oxidation. Whole body or skeletal muscle-specific PHD3 …
Cell：癌症免疫治疗新靶点——PHD3 - 网易
2020年12月13日 · 特别令人感兴趣的是phd3，一种在正常细胞中被证明可以抑制过度脂肪代谢的蛋白质。 与正常环境相比，肥胖环境下癌细胞的PHD3表达明显降低。 蛋白质水平分析证实 …