Pericentriolar material 1, also known as PCM1, is a protein which in humans is encoded by the PCM1 gene. [4][5][6] The PCM1 protein was originally identified by virtue of its distinct cell cycle -dependent association with the centrosome complex and microtubules. The protein appears to associate with the centrosome complex during the cell cycle.

2024年12月25日 · PCM1 (Pericentriolar Material 1) is a Protein Coding gene. Diseases associated with PCM1 include Differentiated Thyroid Carcinoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and Cell Cycle, Mitotic.

2020年11月19日 · We show that ablation of pericentriolar material 1 in the mouse leads to progressive ciliary, anatomical, psychomotor, and cognitive abnormalities. RNAseq reveals changes in amine- and...

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.

Title: Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.

2015年7月20日 · Pcm1-containing centriolar satellites moved along microtubules toward their minus ends, i.e., toward centrosomes, in living cells and in in vitro-reconstituted asters. Immunofluorescence microscopy of mouse nasal respiratory epithelium localized Pcm1 at the apical cytoplasm during ciliogenesis.

2024年6月2日 · The PCM1 gene is located on human chromosome 8 (8p22) and encodes a protein of 2024 amino acids with an approximate weight of 228 kDa (Fig. 2B). It contains 8 coiled-coil domains distributed throughout its structure (Fig. 2B).

PCM1 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

2024年1月31日 · Clinical resource with information about PCM1, The genetic architecture of economic and political preferences., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年6月17日 · Here we find that the centrosome protein Pericentriolar Material 1 (Pcm1), asymmetrically distributed at the centrosomes, regulates polarized endosome dynamics and RGP fate.