2024年12月25日 · PARP14 (Poly(ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Diseases associated with PARP14 include Diphtheria and Tfe3-Rearranged Renal Cell Carcinoma. Among its related pathways are Translation of …

2023年9月13日 · PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed.

2023年9月26日 · We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNγ-treated cancer cell models, in patient melanoma with elevated IFNG expression, and in melanoma cell...

2024年4月26日 · PARP14 is a 203 kDa multi-domain protein that is primarily known as an ADP-ribosyltransferase, and is involved in a variety of cellular functions including DNA damage, microglial activation, inflammation, and cancer progression. In addition, PARP14 ...

Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14 specific inhibitor MCD113 suppress the expression of M2 marker genes in IL-4-polarized primary murine MΦs, in THP-1 monocytic human MΦs, and in primary human monocyte-derived MΦs.

2025年2月9日 · PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1alpha expression. PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells. PARP14 regulates cyclin D1 expression to promote cell-cycle progression.

2023年9月15日 · PARP14 is a mono-ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed.

Schenkel et al. disclose the first highly potent and selective inhibitor of PARP14, RBN012759, an in vitro and in vivo chemical probe. RBN012759 reverses IL-4-driven protumor gene expression in macrophages and induces an inflammatory mRNA signature in primary human tumor explants, suggesting utility of PARP14 inhibitors for treating cancer.

PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating PARP homology domain and its three ADP-ribosyl binding macro domains has been regarded as a potential means of therapeutic intervent …

2021年6月22日 · Here we report that PARP14, a member of the poly(ADP-ribose) polymerase (PARP) family, is a regulator of cyclin D1 expression. Depletion of PARP14 leads to decreased cyclin D1 protein levels.