2012年3月1日 · PRSS1-related hereditary pancreatitis (HP) is characterized by episodes of acute pancreatitis (AP) and recurrent acute pancreatitis (RAP: >1 episode of AP), with frequent progression to chronic pancreatitis (CP).

2024年12月25日 · PRSS1 (Serine Protease 1) is a Protein Coding gene. Diseases associated with PRSS1 include Pancreatitis, Hereditary and Hereditary Chronic Pancreatitis. Among its related pathways are Metabolism of water-soluble vitamins and …

The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is a serine peptidase, which is a type of enzyme that cuts (cleaves) other proteins into smaller pieces. Cationic trypsinogen is produced in the …

Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene. Trypsin-1 is the main isoform of trypsinogen secreted by pancreas, the others are trypsin-2 (anionic trypsinogen), and trypsin-3 (meso-trypsinogen).

2020年1月22日 · PRSS1 蛋白属于一种 T 细胞受体蛋白，是一种调节肿瘤信号转导和活性的重要调节剂，能够快速激活细胞表面的其他蛋白受体 / 配体，从而调节细胞增殖，并通过 MAPK/ERK 信号转导通路参与细胞的增殖、分化和迁移侵袭等病理过程。 肿瘤细胞的迁移能力是反映肿瘤细胞体内发生转移的赞一个重要指标， 细胞迁移实验服务 可以判定某种蛋白对肿瘤细胞的作用。 有研究者观察 PRSS1 低表达对胃癌 MGC803 细胞增殖的影响，并探究了其作用机制。 该研究发 …

2019年9月14日 · In a transgenic mouse model of iZEG-PRSS1_R116C, primary pancreatic intraepithelial neoplasia (PanINs) was observed in the pancreatic duct. These findings suggested a novel pathway mediating pancreatic cancer development, with PRSS1 mutation and overexpression playing an “inside job” role in pancreatic carcinogenesis and tumor development.

2020年1月7日 · prss1水平可用来评估西妥昔单抗的疗效 总之，该研究首次表明，血清PRSS1表达水平和mCRC患者耐药性有关，可作为mCRC的预后标志物，并可作为预测西妥昔单抗治疗mCRC患者疗效的标志物。

该基因编码胰蛋白酶原，它是丝氨酸蛋白酶胰蛋白酶家族的成员。 这种酶由胰腺分泌并在小肠中分解成活性形式。 它对涉及赖氨酸或精氨酸羧基的肽键具有活性。 该基因的突变与遗传性胰腺炎有关。 该基因和其他几个胰蛋白酶原基因定位于 7 号染色体上的 T 细胞受体 β 位点。 [RefSeq 提供，2008 年 7 月] This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This Enzyme is secreted by the pancreas and cleaved to its active form in …

2019年4月25日 · Clinical characteristics: PRSS1-related hereditary pancreatitis (HP) is characterized by episodes of acute pancreatitis (AP) and recurrent acute pancreatitis (RAP: >1 episode of AP), with frequent progression to chronic pancreatitis (CP). Manifestations of acute pancreatitis can range from vague abdominal pain lasting one to three days to ...

Human pancreatic juice contains 3 isoforms of trypsinogen. On the basis of their relative electrophoretic mobility, these are commonly referred to as cationic trypsinogen (PRSS1), anionic trypsinogen (PRSS2; 601564), and mesotrypsinogen (PRSS3; 613578).