2024年12月25日 · PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PIK3CA include Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome and Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi.

The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and related health conditions.

2024年3月1日 · One type of gene mutation that’s known to affect people with breast cancer is called PIK3CA. A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It contributes...

2025年3月3日 · PIK3CA-related overgrowth spectrum (PROS) includes a group of genetic disorders that leads to overgrowth of various body parts due to changes (variants) in the gene PIK3CA. This gene is involved in making a protein that helps regulate cell …

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit.

2013年8月15日 · PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia.

Perhaps one of the most interesting and surprising recent findings in the PIK3CA field was the recent report of common hotspot mutations of PIK3CA in two benign skin lesions – epidermal nevi and seborrheic keratoses (SK), two noninvasive keratinocyte-derived skin tumors.