
PIAS1 - Wikipedia
It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in …
PIAS1 Gene - GeneCards | PIAS1 Protein | PIAS1 Antibody
2024年12月25日 · PIAS1 (Protein Inhibitor Of Activated STAT 1) is a Protein Coding gene. Diseases associated with PIAS1 include Nephronophthisis and Germ Cell Cancer. Among its …
PIAS1包含了一个内在的激活结构域,对雄激素受体的转录有双向的功能,使得低水平表达能抑制转录,高水平的表达能诱导转录。 由于PIAS1中该结构域的存在,PIAS1与其他成员相比在调节雄激 …
Nat Commun: SUMO化修饰组学揭示PIAS1新底物蛋白及 ... - 搜狐
2020年2月28日 · PIAS1 (protein inhibitor of activated STAT1)蛋白是一种可以抑制信号转导与转录激活子1 (STAT1)的特异性抑制蛋白,同时具有SUMO连接酶E3的活性,参与多种转录因子的 …
激活的 STAT 1 蛋白抑制因子(PIAS1)基因 | MCE
该基因编码激活 STAT (PIAS) 蛋白抑制剂家族的成员。 PIAS 蛋白作为 SUMO E3 连接酶发挥作用,并通过介导靶蛋白的 SUMO 化在许多细胞过程中发挥重要作用。 这种蛋白质作为众多细胞 …
PIAS1 protein inhibitor of activated STAT 1 [ Homo sapiens …
2025年3月8日 · Title: SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer. Crosstalk between …
Quantitative SUMO proteomics identifies PIAS1 substrates …
2020年2月11日 · Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers. Here we used quantitative SUMO …
PIAS1与肿瘤 - 中国生物化学与分子生物学报
2017年5月1日 · PIAS1(protein inhibitor of activated signal transducer and activators of transcription 1)蛋白是一种可以抑制信号转导与转录激活子1(signal transducer and …
Protein inhibitor of activated STAT1 (PIAS1) alleviates cerebral ...
2024年4月15日 · Protein inhibitor of activated signal transducer and activators of transcription 1 (PIAS1) is a small ubiquitin-like modifier (SUMO) E3 ligase, which plays a crucial role in …
Regulation of gene-activation pathways by PIAS proteins in the
2005年8月1日 · PIAS1 has specific effects on cytokine-mediated signalling by selectively regulating a subset of interferon- or tumour-necrosis-factor-responsive genes. PIAS1 is …
PIAS1与肿瘤 - pku.edu.cn
PIAS1 (protein inhibitor of activated signal transducer and activators of transcription 1)蛋白是一种可以抑制信号转导与转录激活子1 (signal transducer and activators of transcription...
Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) …
2012年11月29日 · Protein inhibitor of activated signal transducer and activator of transcription-1 (PIAS1) is known to function as small ubiquitin-like modifier (SUMO) E3 ligase as well as …
PIAS1 selectively inhibits interferon-inducible genes and is
2004年8月15日 · Using PIAS1-deficient cells, we show that PIAS1 selectively regulates a subset of IFN-γ- or IFN-β-inducible genes by interfering with the recruitment of STAT1 to the gene …
Frontiers | PIAS family in cancer: from basic mechanisms to clinical ...
2024年3月24日 · Most frequently reported PIAS family members in cancer development are PIAS1 and PIAS3. SUMOylation as post-translational modifier regulates several cellular …
PIAS1 Regulates Breast Tumorigenesis through Selective ... - PLOS
2014年2月24日 · We report here that the PIAS1 SUMO ligase is involved in the progression of breast tumorigenesis. Elevated PIAS1 expression was observed in breast tumor samples. …
Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 ...
2007年6月1日 · Protein inhibitor of activated STAT1 (PIAS1), a transcriptional regulator that possesses small ubiquitin-related modifier (SUMO) E3 ligase activity, inhibits immune …
PIAS1 impedes vascular endothelial injury and atherosclerotic …
2023年8月16日 · Our study proved that PIAS1 suppressed vascular endothelial injury and atherosclerotic plaque formation in mouse models of diabetes via the RUNX3/TSP-1 axis. …
Protein inhibitor of activated STAT - Wikipedia
The discovery of PIAS3 was first published in 1997. The discovery was made while the JAK-STAT pathway was being studied. [1] The discovery of other PIAS proteins, including PIAS1, …
Quantitative SUMO proteomics identifies PIAS1 substrates involved …
2020年2月11日 · The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is …
The Ligase PIAS1 Restricts Natural Regulatory T Cell ... - Science
2010年10月22日 · We report here that the SUMO E3 ligase PIAS1 restricts the differentiation of natural T reg cells by maintaining a repressive chromatin state of the Foxp3 promoter. PIAS1 …