2024年12月25日 · P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. Diseases associated with P2RY6 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 and Parkinson's Disease. Among its related pathways are Purinergic signaling and GPCR downstream signalling.

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene. [5][6] The product of this gene, P2Y 6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides.

该基因的产物属于 P2 受体家族，由细胞外核苷酸激活，细分为 P2X 配体门控离子通道和 P2Y G 蛋白偶联受体。 该家族有几种具有不同药理学选择性的受体亚型，在某些情况下，它们对各种腺苷和尿苷核苷酸有重叠。 该受体是一种 G 蛋白偶联受体，对 UDP 有反应，对 UTP 和 ADP 有部分反应，对 ATP 没有反应。 有人提出该受体介导炎症反应。 可变剪接导致编码不同蛋白质亚型的多个转录变体。 [RefSeq 提供，2013 年 3 月]

2025年2月8日 · Title: Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production. Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.

Diseases associated with P2RY6 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 and Parkinson's Disease. Among its related pathways are Purinergic signaling and GPCR downstream signalling.

2025年3月7日 · 该研究首次鉴定了神经酰胺的内源性受体——cysltr2 和 p2ry6，阐明了神经酰胺加重动脉粥样硬化的作用及分子机制，解析了神经酰胺-cysltr2 复合物结构。

2024年7月23日 · In mouse syngeneic and human xenograft tumor models, ectopic expression of P2RY6 shapes an immunosuppressive tumor microenvironment (TME) to enhance tumor growth and resistance to immunotherapy, whereas deletion of P2RY6 from tumors with high P2RY6 expression inflames the TME to inhibit tumor growth. As a G protein-coupled receptor, P2RY6 ...

Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Apr 2022]

2025年3月8日 · 为了明确CYSLTR2和P2RY6是否介导神经酰胺的致病作用，研究团队通过构建动脉粥样硬化模型，发现 Cysltr2-/-小鼠或 P2ry6-/-小鼠，虽然血浆胆固醇和神经酰胺的水平无显著变化，但高脂饮食诱导或外源性神经酰胺C16:0回补所加重的动脉粥样硬化均显著减轻，双敲除两个 ...

作为 g 蛋白偶联受体，p2ry6 激活 gq/磷脂酶 c-β 信号传导并刺激前列腺素 e2 的合成，前列腺素 e2 是 tme 中免疫抑制的关键介质。与 p2ry6 在肿瘤中的重要作用相反，小鼠的全局缺失不会影响活力。