冬凌草甲素，外文名称为Oridonin，是从唇形科(Iabtea)香茶菜属(Rabdosia)植物中分离出来的一种有生物活性的天然物质。 其主要成分为贝壳杉烷型四环二萜类天然有机化合物(ent-kau …

2018年6月29日 · Ori forms a covalent bond with the cysteine 279 of NLRP3 in NACHT domain to block the interaction between NLRP3 and NEK7, thereby inhibiting NLRP3 inflammasome …

Oridonin is an organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens. It has a role …

2021年7月5日 · New evidence shows that oridonin possesses a wide range of pharmacological properties, including anticancer, anti-inflammatory, hepatorenal activities as well as …

2021年7月5日 · Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is widely present in numerous Chinese medicine …

2021年7月1日 · Hundreds of oridonin derivative analogs (oridonalogs) have been synthesized and screened for improved potency, bioavailability, and other drug properties. Particularly, many of …

Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC 50 s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti …

冬凌草甲素（Oridonin，Ori）是中草药冬凌草（Rabdosia rubescens）的主要成分，具备抗肿瘤【2,3】、抗炎效果，但是其抗炎作用的靶点并不清楚。 过去有一些研究表明，冬凌草甲素可以 …

2025年2月1日 · Oridonin, an anticancer agent derived from the herbs of the Rabdosia rubescens plant, has shown promise in causing cell death (apoptosis) and self-digestion (autophagy) in …

2016年8月24日 · Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon species. It exhibits inhibitory activities against a variety of tumor cells, and …