
OPN5 - Wikipedia
Opsin-5, also known as G-protein coupled receptor 136 or neuropsin is a protein that in humans is encoded by the OPN5 gene. Opsin-5 is a member of the opsin subfamily of the G protein-coupled receptors .
OPN5 Gene - GeneCards | OPN5 Protein | OPN5 Antibody
2024年12月25日 · OPN5 (Opsin 5) is a Protein Coding gene. Diseases associated with OPN5 include Cycloplegia. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 11-cis retinal binding.
Violet-light suppression of thermogenesis by opsin 5 ... - Nature
2020年9月2日 · Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light 1, 2. In mice, OPN5 is a known photoreceptor in the retina 3 and skin 4 but is also...
Opn5 及其同系物的分子特性、操作和潜在用途,Journal of …
动物视蛋白家族中的视蛋白 5 (Opn5) 组包含多种相关蛋白,例如 Opn5m,一种在包括哺乳动物在内的所有脊椎动物谱系中保守的蛋白,以及在非哺乳动物脊椎动物基因组中发现的其他成员,如 Opn5L1 和 Opn5L2,以及Opn6 存在于非兽类脊椎动物基因组中,Opn5 同源物也 ...
Selective optogenetic control of Gq signaling using human
2022年4月1日 · Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity...
UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice
2011年10月17日 · OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner. Immuno-blotting analyses of mouse tissue extracts identified the retina, the brain and, unexpectedly, the outer ears as the major sites of OPN5 expression.
Molecular Property, Manipulation, and Potential Use of Opn5 and …
2024年3月1日 · The Opsin 5 (Opn5) group within the animal opsin family comprises a diverse array of related proteins, such as Opn5m, a protein conserved across all vertebrate lineages including mammals, and other members like Opn5L1 and Opn5L2 found in non-mammalian vertebrate genomes, and Opn6 found in non-therian vertebrate genomes, along with …
Neuropsin (OPN5) Mediates Local Light-Dependent Induction of …
2019年10月21日 · Here, we assess the function of a population of melanocyte precursor cells in hair and vibrissal follicles that express the photopigment neuropsin (OPN5). Organotypic cultures of murine outer ear and vibrissal skin entrain to a light-dark cycle ex vivo, requiring cis-retinal chromophore and Opn5 gene function.
Neuropsin (Opn5): a novel opsin identified in mammalian neural …
2003年11月20日 · We report the isolation of a novel mammalian opsin-like gene, Opn5, the first member of a new opsin family. We have determined its gene structure, chromosomal localisation and tissue expression pattern in mice and humans.
An opsin 5–dopamine pathway mediates light-dependent ... - Nature
2019年4月1日 · Here, we show that opsin 5 (OPN5; also known as neuropsin)-dependent retinal light responses regulate vascular development in the postnatal eye. In Opn5 -null mice, hyaloid vessels regress...