2024年12月25日 · OPN4 (Opsin 4) is a Protein Coding gene. Diseases associated with OPN4 include Seasonal Affective Disorder and Retinal Degeneration. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4. [5] In the mammalian retina , there are two additional categories of opsins, both involved in the formation of visual images: rhodopsin and photopsin (types I, II, and III) in the rod and cone ...

表达 黑视蛋白 (OPN4) 的内源性光敏视网膜神经节细胞 (ipRGC) 将视网膜感光器驱动的光信息传送到大脑。然而，除了这种依赖于同步因子的方式外，光也可以独立于昼夜节律的方式影响睡眠。

2023年10月18日 · OPN4 is a G protein-coupled receptor initially identified in the dermal melanocytes of Xenopus laevis. It includes an extracellular amino-terminal and seven transmembrane domains...

2016年1月15日 · In this review, we shall overview the current understanding of the melanopsin system, and evaluate the evidence for the hypothesis that individual pRGC subtypes not only perform specific roles, but...

2023年3月23日 · 视黑质是一种新近发现的、主要分布于视网膜神经节细胞的光感受器视蛋白，由Opn4基因编码。 Opn4敲除小鼠在接受长时间黑暗环境和短暂白光环境后进行十字高架实验和旷场实验后并不表现出焦虑样行为。 进一步通过 特异性损害ipRGCs后小鼠在接受上述光照暴露后也不表现出焦虑水平。 免疫荧光实验分别检测小鼠暴露在黑暗环境和白光环境中大脑神经元激活状态，结果发现白光环境显著激活视交叉上核、腹侧膝状核、中央杏仁核（CeA)、终纹床 …

2025年1月13日 · Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes. Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects. Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes.

视蛋白是鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体超家族的成员。 该基因编码一种感光视蛋白，该视蛋白在视网膜的神经节和无长突细胞层中表达。 在小鼠中，表达该基因的视网膜神经节细胞轴突投射到视交叉上核和其他参与昼夜节律光夹带的脑核。 在小鼠中，该蛋白通过 G 蛋白信号通路与瞬时受体电位 (TRP) 离子通道偶联，并通过膜去极化和增加细胞内钙产生生理光反应。 该蛋白质起着感官感光色素的作用，也可能具有光异构酶活性。 用基因敲除小鼠进行的实验表 …

OPN4 (melanopsin) expression was first identified in the skin of amphibians; however, whether it is also expressed and functioned in the human skin has not yet been identified. Here, we show that OPN4 was expressed in the human skin tissue and cultures of isolated keratinocytes, melanocytes and fibroblasts.

2017年10月25日 · Melanopsin (OPN4) is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina. These cells play a role in synchronizing the central circadian pacemaker to the astronomical day by conveying information about ambient light to the hypothala …