2024年12月25日 · OPN3 (Opsin 3) is a Protein Coding gene. Diseases associated with OPN3 include Acral Lentiginous Melanoma and Retinitis Pigmentosa. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Opsin-3 also known as encephalopsin or panopsin[4] is a protein that, in humans, is encoded by the OPN3 gene. [5][6][7] Alternative splicing of this gene results in multiple transcript variants encoding different protein isoforms. [8] Opsins are members of the …

2022年2月18日 · Emerging cell- or tissue-based evidence has demonstrated that opsin 3 (OPN3) mediates a variety of pathological processes affecting tumorigenesis, clinical prognosis, and treatment resistance in some cancers. However, a comprehensive analysis of OPN3 across human cancers is unavailable.

2023年6月1日 · Using OPN3-targeted siRNA, the downregulation of OPN3 mRNA (by >70% compared to control cells) suppressed the production of interleukin-2 (IL-2), a cytokine important for immunomodulation, which suggests a potential previously unknown role for OPN3 in T-cell signaling processes.

2020年5月2日 · 这项研究证明,一种称为 OPN3 的 OPN 在 UVA 暴露后,在 HDF 中的 MMP1、MMP2、MMP3 和 MMP9 产生中发挥作用。 这提供了对人类皮肤细胞对 UVA 辐射反应的分子机制的了解,并可能揭示预防或治疗皮肤光老化的分子靶标。 本摘要涉及研究:Opsin 3 是人真皮成纤维细胞中紫外线 A 诱导光老化的关键调节因子。 Summary 我们的皮肤经常暴露于阳光中的紫外线辐射下。 长期暴露于紫外线辐射 (主要是一种称为 UVA 的紫外线)会使称为人真皮成纤维细胞 …

OPN3 and the multimeric tyrosinase/tyrosinase-related protein complex induced after its activation appear as new potential targets for regulating melanogenesis but also to protect dark skins against blue light in physiological conditions and in pigmentary disorders.

2019年6月4日 · Opsin 3 (OPN3 or encephalopsin), initially identified in the brain, remains one of the few members of the mammalian opsin family with unknown function and ambiguous light absorption properties. We recently discovered that OPN3 is highly expressed in human epidermal melanocytes (HEMs)-the skin cells that produce melanin.

2019年10月20日 · opn3在成纤维细胞中高度表达，对uva辐射有反应。 OPN3通过钙依赖性G蛋白偶联的信号通路调节MMP1，MMP2，MMP3和MMP9的表达。 OPN3是一种光敏传感器，在皮肤的光老化过程中起着重要的作用。

In mice, we found that Opn3 in Mc4r-expressing neurons regulates food consumption. Our results reveal the first mechanistic insight into OPN3 function in the hypothalamus, uncovering a unique mechanism by which OPN3 functions to potentiate Kir7.1 activity and negatively regulate MC4R-mediated cAMP signaling, thereby promoting food intake.

这种基因，即视蛋白 3，在大脑和睾丸中表达强烈，在肝脏、胎盘、心脏、肺、骨骼肌、肾脏和胰腺中表达微弱。 该基因也可以在视网膜中表达。 该蛋白质具有感光视蛋白的典型特征。 [RefSeq 提供，2008 年 7 月] Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues.