As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics bu …

Slc22a7 or Oat2 is a multispecific organic anion transporter with high expression in the liver and kidney (124, 129, 187). This transporter displays a much broader pattern of expression in the developing mouse embryo, where it is expressed in the lungs, developing bone/cartilage and kidney, as well as the liver ( 187 ).

Most likely acting as an organic anion/dicarboxylate exchanger, OAT2 mediates the transport of endogenous molecules including dicarboxylic acids, nucleotides and uric acid, lipid hormones and mediators, and creatinine, as well as xenobiotics such …

2022年10月21日 · Organic anion transporter 2 (OAT2 or SLC22A7) plays an important role in the hepatic uptake and renal secretion of several endogenous compounds and drugs. The goal of this work is to understand the structure activity of OAT2 …

Organic anion transporters (OATs), a subfamily of the solute carrier 22 (SLC22) transporters, are localized on the physiological barriers of multiple tissues, such as kidney, liver, brain, placenta, retina, and olfactory mucosa (He, et al., 2014; S. K. Nigam, et al., 2015).

Superfamily SLCO (formerly SLC21A) consists of organic anion transporting polypeptides (OATPs), while the organic anion transporters (OATs) and the organic cation transporters (OCTs) are classified in the SLC22A superfamily.

In the present investigation, the transport of creatinine was assessed in human embryonic kidney (HEK) cells that stably expressed human OAT2 (OAT2-HEK) and isolated human renal proximal tubule cells (HRPTCs). The tubular localization of OAT2 in …

2017年2月1日 · To summarize, our results identify that human OAT2 is an ETV transporter, thereby suggesting that it plays an important part in the mechanisms underlying ETV antiviral activity.

2015年10月6日 · Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described – OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), …

2012年3月6日 · OAT2 was first discovered in 1998 and termed “novel liver transporter” (NLT) (Simonson, Vincent, Roberg, Huang, & Iwanij, 1994). (Sekine et al., 1998) suggested to rename NLT to OAT2 because of its ability to transport organic anions such as salicylate, dicarboxylates and para-aminohippurate.