2024年12月25日 · NUAK1 (NUAK Family Kinase 1) is a Protein Coding gene. Diseases associated with NUAK1 include Omphalocele and Endometrial Squamous Cell Carcinoma. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. [5] [6] [7]

单细胞 RNA 测序表明，Nuak1抑制剂治疗可改善肿瘤免疫微环境，与共刺激受体激动剂或过继性 T 细胞治疗联合使用时，能进一步增强抗肿瘤效果。研究还发现，NUAK1 阻断会导致甲羟戊酸途径和胆固醇生物合成的过度激活。

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2024年3月21日 · Here, the authors uncovered that the AMPK-related kinase NUAK1 controls axonal mitochondrial metabolism through the regulation of the mitochondrial microprotein BRAWNIN.

2020年9月1日 · Depletion of NUAK1 by siRNA or small molecule inhibitors prolongs survival in mouse models of different tumors, demonstrating that targeting cellular energy homeostasis by inhibiting NUAK1 is a...

2022年4月6日 · In mouse models, fibroblast-specific NUAK1 deletion or treatment with the NUAK inhibitor HTH-02-006 protected against fibrosis of multiple organs; the inhibitor also reduced established kidney ...

nuak1是一种位于细胞质和细胞核中的ampk相关激酶，其表达与多种肿瘤的恶性肿瘤和患者预后不良相关。 因此，NUAK1与转移相关，因为它促进不同癌细胞中的细胞迁移和侵袭。

lkb1 / nuak1激活通过诱导p21 / waf1的表达导致细胞周期停滞在g（1）/ s边界。 在LKB1的调控下，NUAK1与细胞核中的p53相互作用并与p21 / WAF1启动子的p53反应元件结合。

2022年3月23日 · Here, we describe NUAK family kinase 1 (NUAK1) as a TGF-β-inducible profibrotic kinase that is up-regulated in multiple fibrotic organs in mice and humans. Mechanistically, we show that TGF-β induces a rapid increase in NUAK1 in fibroblasts. NUAK1, in turn, can promote profibrotic YAP and TGF-β/SMAD signaling, ultimately leading to organ ...