Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they …

The identification of cancer patients harboring NTRK gene fusions is constantly growing, especially with the advent of NTRK inhibitors. This has promisingly provided a rationale for …

In this Review, we discuss the biology of NTRK fusions, strategies to target these drivers in the treatment-naive and acquired-resistance disease settings, and the unique safety profile of …

NTRK fusions are clinically actionable: first-generation TRK tyrosine kinase inhibitors (larotrectinib or entrectinib) result in histology-agnostic responses in both adult and paediatric patients with …

2021年9月16日 · Neurotrophic tropomyosin-receptor kinase (NTRK) genes encode a family of transmembrane-receptor tyrosine kinases that play an important role in neural development. …

Neurotrophic tyrosine receptor kinase (NTRK) has been a remarkable therapeutic target for treating different malignancies, playing an essential role in oncogenic signaling pathways.

2021年7月20日 · Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers in solid tumours. This study aimed to interrogate a large real-world database …

NTRK gene fusions are one such targetable aberration. The neurotrophin receptor tyrosine kinase (NTRK) family is made up of 3 genes crucial to nervous system development and physiology. …

2023年3月13日 · NTRK gene fusions are rare somatic mutations found across cancer types with promising targeted therapies emerging. Healthcare systems face significant challenges in …

NTRK is an important biomarker that can impact lung what treatment options. The videos above were produced in 2020. For the latest treatment options, speak with your doctor. What is an …