2024年12月25日 · NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include Chondrosarcoma, Extraskeletal Myxoid and Chondrosarcoma. Among its related pathways are Gene …

本研究首次揭示血管平滑肌细胞NR4A3在动脉中层钙化中的重要作用，发现NR4A3介导的糖酵解增强和乳酸增多促进Phospho1启动子区域组蛋白H3K18位点的乳酰化修饰，最终促进了动脉钙化的发生。

The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. [5] NR4A3 is a member of the nuclear receptor family of …

This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases. Keywords: NOR-1, cardiovascular remodeling, atherosclerosis, abdominal aortic aneurysm

2020年8月31日 · Here, we show that Nr4a1 and Nr4a3 play partially redundant roles to restrain B cell responses to antigen in the absence of co-stimulation and do so, in part, by repressing the expression of BATF...

核受体亚家族 4 A 组成员 3： 该基因编码类固醇-甲状腺激素-类视黄醇受体超家族的成员。编码的蛋白质可以充当转录激活剂。该蛋白可有效结合 NGFI-B 反应元件 (NBRE) 。三种不同版本的骨骼外粘液样软骨肉瘤 (EMC) 是该基因与其他基因相互易位的结果。易位断点与核受体亚科 4、A 组、成员 3 (在 9 号 ...

2018年11月19日 · To confirm that NR4A3 is a direct transcriptional target of p53 and identify specific region(s) of the NR4A3 promoter that contains functional p53 response elements (p53RE), we employed...

Low expression of NR4A gene family members (NR4A1, NR4A3) and 1-alpha25-dihydroxyvitamin D3 receptor (VDR) genes is demonstrated in peripheral blood mononuclear cells of multiple sclerosis patients. The pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cellular extraskeletal myxoid chondrosarcomas.

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes induced by multiple stressors, and the NR4A1 receptors play an important role in maintaining cellular homeostasis and disease. There is increasing evidence for the role of ...

2024年1月23日 · At present, research on the role of Nr4a3 in the pathophysiology of inflammation is considerably limited, especially with respect to its role in the central nervous system (CNS). In this review, we discuss the role of Nr4a3 in multiple sclerosis, Alzheimer’s disease, retinopathy, Parkinson’s disease, and other CNS diseases.