2024年12月25日 · NLRP4 (NLR Family Pyrin Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRP4 include Cinca Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. An important paralog of this gene is NLRP9.

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

2024年8月26日 · Our findings revealed that NLRP4 upregulation contributes to increased resistance to olaparib in pancreatic cancer cells, both in vitro and in vivo. RNA sequencing and Co-IP MS analysis revealed...

This study provides evidence that NLRP4, a constituent of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, imparts resistance to olaparib in pancreatic cancer

2024年11月28日 · NLRP4 is a member of NLR family of cytosolic receptors and a member of an inflammation signaling cascade. Despite being important for activation of inflammatory responses and having some similarities with other known ASC-interacting PYDs, NLRP4 does not interact with the adaptor protein ASC and its complementary charged surface is a major ...

2012年3月4日 · Here we report that the pattern-recognition receptor NLRP4 regulated the activation of type I interferon mediated by double-stranded RNA or DNA by targeting the kinase TBK1 for degradation....

2024年8月27日 · 这项研究表明，NLRP4是核苷酸结合和寡聚化结构域样受体（NLR）家族的组成部分， 在体外和体内均赋予胰腺癌细胞对奥拉帕尼的耐药性。 从机制上讲，NLRP4促进DNA修复并触发活性氧（ROS）和自噬水平升高，这似乎在PARPi的耐药性发展中，发挥作用。 研究进展. NLRP4诱导的自噬与胰腺癌细胞中的线粒体ROS相关，以响应奥拉帕尼治疗. 奥拉帕尼给药后，NLRP4敲除的BxPC-3和Capan-1细胞中的红色和黄色荧光强度（分别代表自噬溶酶体和自 …

2025年2月8日 · NLRP4 binds ARHGDIA (Rho GDP dissociation inhibitor alpha) to regulate Rho GTPase signaling and facilitate actin-mediated xenophagy. The minor allele of rs16986718G > A in NLRP4 may be a genetic marker that predicts asthma exacerbation in adult asthmatics who smoke. NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo.

5 天之前 · nlrp4 过表达与良好预后相关：研究人员筛选出 nlrp4 进行研究，发现 nsclc 是 nlrp4 基因组改变的第三大常见癌症类型，其突变占比达 5.89%。nlrp4 基因组突变与 mrna 水平的过表达相关，且高表达 nlrp4 与更好的总生存期（os）和无复发生存期（rfs）相关。

6 天之前 · NLRP4 could trigger a distinct anti-tumor ecosystem organized by TIGIT+TNFA+ NK and iNOS+ M1 in lung cancer, discovered in TCGA analysis and verified in murine model. NLRP4-eco exerted tumor-suppression capacity through chemokine reprogramming including CCL5 and CXCL2. Meanwhile, the cytoxicity of NK could be facilitated by iNOS+M1.