2024年12月25日 · NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Diseases associated with NLRC3 include Cinca Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. An important paralog of this gene is NLRP12.

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. [5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 …

2016年12月12日 · NLRC3 (also known as CLR16.2 or NOD3) is a poorly characterized member of the NLR family and was identified in a genomic screen for genes encoding proteins bearing leucine-rich repeats (LRRs) and...

2022年10月4日 · NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells.

2024年1月3日 · In this study, we find that Nlrc3, a nucleotide-binding domain leucine-rich repeat containing family gene, is highly expressed in hematopoietic differentiation stages in vivo and vitro and is...

In this study, high levels of NOD-like receptor family CARD domain containing-3 (NLRC3) correlated with the glycolytic defects of monocytes/macrophages from septic patients and mice that developed immunosuppression. Myeloid-specific NLRC3 deletion improved macrophage glycolysis and sepsis-induced immunosuppression.

2022年10月20日 · NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells. In macrophages, NLRC3 inhibits the activation of the NF-κB signaling pathway, the STI …

Ablation of the Nlrc3 gene led to enhanced anti-viral cytokine production and viral clearance in culture. Most important, HSV-1-infected Nlrc3 −/− mice exhibited greatly reduced morbidity, enhanced interferon and cytokine production and reduced viral load. This work demonstrates that NLR is a negative regulator of innate immunity triggered ...

2025年2月8日 · NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma. [Knockdown of NLRC3 promotes proliferation and invasion of human colon cancer cells]. NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6/JAK2/STAT3 pathway activation.

2019年8月15日 · NLRC3 negatively regulates the antigen-presenting function of DCs via p38 signaling pathway. Vaccination with NLRC3-overexpressed DCs reduces EAE progression. Our findings support that NLRC3 serves as a potential target for treating adaptive immune responses driving multiple sclerosis and other autoimmune disorders.