Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the central nervous system, peripheral nervous system and in myogenic and other tissues.

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with ...

2024年12月25日 · NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Embryonal Carcinoma and Periventricular Leukomalacia. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Neural Stem Cells and Lineage-specific Markers.

Nestin is an intermediate filament protein that is known as a neural stem/progenitor cell marker. It is expressed in undifferentiated central nervous system (CNS) cells during development, but also in normal adult CNS and in CNS tumor cells.

2024年7月1日 · In general, in nestin + stem cells and adult cells that re-express nestin after injury, nestin often directly affects cell biological behaviours such as proliferation, apoptosis and migration regulation in response to different tissue injuries.

2022年10月24日 · Nestin, a class VI intermediate filament protein, is a specific marker of neural stem/progenitor cells 5. Embryonic nestin-positive cells can differentiate into neurons and glial cells.

2011年4月7日 · Neurons and glial cells in the developing brain arise from neural progenitor cells (NPCs). Nestin, an intermediate filament protein, is thought to be expressed exclusively by NPCs in the normal brain, and is replaced by the expression of proteins specific for neurons or glia in differentiated cells.

2018年10月2日 · Our study challenges the dogma that nestin is a marker of proliferation, and provides insight into its regulation and function in EC.

This review highlights the potential of nestin as a marker of multilineage stem/progenitor cells, and as a key factor in tissue development and tissue regeneration. The article discussed the current findings, limitations, and potential clinical implications or applications of nestin + cell …

This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton.