
NSD1 Gene - GeneCards | NSD1 Protein | NSD1 Antibody
2024年12月25日 · NSD1 (Nuclear Receptor Binding SET Domain Protein 1) is a Protein Coding gene. Diseases associated with NSD1 include Sotos Syndrome and Beckwith-Wiedemann Syndrome. Among its related pathways are PKMTs methylate histone lysines and …
NSD1 - 百度百科
NSD1在胚胎早期发育中起调节作用,其表达异常与Sotos 综合症密切相关。 我们解析了NSD1催化中心与甲基供体复合物1.7 Å分辨率的三维晶体结构(图2A),并通过计算机动力学模拟了其与底物核小体之间的作用方式(图2B)。 通过结构分析及比对,寻找到一个关键的调节loop(图2C),NSD1与核小体结合后可诱导该loop区域的构象变化,开启H3K36与活性中心甲基供体间的相互作用。 这些对我们理解NSD1以核小体为底物的底物特异性、 甲基转移酶 作用机理以及 …
靶向组蛋白甲基转移酶NSD家族的抗肿瘤小分子抑制剂研究进展
nsd家族包括nsd1、nsd2(又称为mmset或whsc1)和nsd3(又称为whsc1l1)三个成员,在多种疾病的发生和发展中都发挥着重要作用。比如,nsd1功能突变和缺失会引起索托氏综合征,nsd2的单倍体不足会导致心脏缺陷等。此外,研究表明nsds的过度表达和改变与许多癌症相关。
NSD1: A Lysine Methyltransferase between Developmental …
Recurrent epigenomic alterations associated with multiple human pathologies have increased the interest in the nuclear receptor binding SET domain protein 1 (NSD1) lysine methyltransferase. Here, we review the current knowledge about the biochemistry, cellular function and role of NSD1 in human diseases.
NSD1 supports cell growth and regulates autophagy in HPV
2024年2月13日 · NSD1 is a histone methyltransferase that catalyzes histone H3 lysine 36 di-methylation (H3K36me 2); mutations inactivating NSD1 have been linked to improved outcomes in...
《爱求索》之靶点探索篇——靶向治疗中NSD 1、NSD 2、|靶向治 …
2022年9月27日 · NSD蛋白家族(nuclear receptor binding SET domain proteins)包含三个成员: NSD1、NSD2(又名MMSET或WHSC1)和NSD3(又名WHSC1L1) ,是与肿瘤发生相关的组蛋白甲基化转移酶,对维持染色质稳定和基因表达调控具有重要作用[1]。
NSD1 gene - MedlinePlus
The NSD1 gene provides instructions for making a protein that functions as a histone methyltransferase. Histone methyltransferases are enzymes that modify structural proteins called histones, which attach (bind) to DNA and give chromosomes their shape.
NSD1 - Wikipedia
NSD1 (Nuclear receptor binding SET Domain Protein 1) [5] is a transcription coregulator protein [6] that encodes Histone Methyltransferase and is associated with Sotos syndrome [7] and Weaver syndrome.
NUCLEAR RECEPTOR-BINDING SET DOMAIN PROTEIN 1; NSD1 …
HGNC Approved Gene Symbol: NSD1. Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38) : 5:177,131,798-177,300,213 (from NCBI) The androgen receptor (AR; 313700) is a member of the steroid receptor (SR) superfamily that interacts with DNA response elements.
Histone methylation mediated by NSD1 is required for the …
2023年12月26日 · Here we showed that NSD1, the methyltransferase for di-methylated lysine 36 of histone H3 (H3K36me2), controls both area and layer identities of the neocortex. Nsd1 -ablated neocortex showed an area shift of all four primary functional regions and aberrant wiring of cortico-thalamic-cortical projections.