NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to …

2024年12月25日 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Acute Myeloid Leukaemia With Myelodysplasia-Related Features and Leukemia, Acute Myeloid. Among its related pathways are Transport of the SLBP independent Mature mRNA and Signaling by ALK fusions and activated point mutants.

2021年2月4日 · Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia (AML).

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly ...

2022年8月25日 · NPM1 mutations are the most common genetic alteration in acute myeloid leukemia (AML), detected in about 30–35% of adult AML and more than 50% of AML with normal karyotype.

2020年10月8日 · The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministical …

2024年12月17日 · Thanks to its property to act as histone chaperone and to shuttle between the nucleus and cytoplasm, the NPM1 protein is involved in multiple cellular function that are here extensively reviewed...

The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the cell called the nucleolus. Learn about this gene and related health conditions.

2024年11月25日 · 核磷蛋白（npm1）是最丰富的核仁蛋白之一，npm1基因的突变与多种血液系统恶性肿瘤相关，包括急性髓系白血病（aml）。 有研究表明，NPM1通过促进细胞增殖和抑制细胞凋亡在多种实体瘤中发挥致癌作用。

该基因编码的蛋白质参与多种细胞过程，包括中心体复制、蛋白质伴侣和细胞增殖。 编码的磷蛋白在核仁、细胞核和细胞质之间穿梭，陪伴核糖体蛋白和核心组蛋白从细胞核到细胞质。 还已知这种蛋白质将肿瘤抑制因子 ARF 隔离在核仁中，保护它免于降解，直到需要它为止。 该基因的突变与急性髓性白血病有关。 已经鉴定出该基因的数十个假基因。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is involved in several cellular processes, including centrosome …