Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells [5] as well as in hepatocytes. [6] Specifically, it appears to bind to a critical mediator of cholesterol absorption. The drug ezetimibe inhibits NPC1L1 causing a reduction in cholesterol absorption, resulting in a blood cholesterol reduction of ...

2021年7月18日 · NPC1L1 是一种含有 1332 个氨基酸的膜蛋白，位于哺乳动物小肠的刷状膜和灵长类动物的肝细胞小管膜上。NPC1L1 序列与 Niemann-Pick 病 C1 型 (NPC1)具有 42% 的同一性和 51% 的相似性，后者是一种在晚期内体/溶酶体中起作用的膜蛋白。

2024年12月25日 · NPC1L1 (NPC1 Like Intracellular Cholesterol Transporter 1) is a Protein Coding gene. Diseases associated with NPC1L1 include Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 7 and Lipodystrophy, Congenital Generalized, Type 1 .

关于 npc1l1 Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,512,535-44,541,330 (from NCBI) This gene has 4 transcripts (splice variants), 190 orthologues, 10 paralogues and is associated with 2 phenotypes.

NPC1L1 is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that is widely used in treating hypercholesterolemia. Recent findings suggest that NPC1L1 deficiency or ezetimibe treatment also prevents diet-induced hepatic steatosis and obesity in addition to reducing blood cholesterol.

NPC1L1 mediates intestinal cholesterol absorption and it may also limit hepatobiliary cholesterol excretion, particularly in humans. Thus, NPC1L1 may have evolved to protect the body against excessive loss of cholesterol, a structural component of the cell membrane. Evidence supports NPC1L1 being the molecular target of ezetimibe.

2023年10月13日 · Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic recycling compartment (ERC).

Both intestinal NPC1L1 and hepatic NPC1L1 are targets of the cholesterol-lowering drug ezetimibe. NPC1L1-dependent cholesterol uptake may be a clathrin-mediated endocytic process. Animal studies show that genetic inactivation of NPC1L1 or ezetimibe treatment attenuates atherosclerosis, NAFLD, insulin resistance, and, under certain circumstances ...

2021年7月19日 · NPC1L1 是一种含有 1332 个氨基酸的膜蛋白，位于哺乳动物小肠的刷状膜和灵长类动物的肝细胞小管膜上。NPC1L1 序列与 Niemann-Pick 病 C1 型 (NPC1)具有 42% 的同一性和 51% 的相似性，后者是一种在晚期内体/溶酶体中起作用的膜蛋白。

2021年7月16日 · Niemann-Pick C1-like 1 (NPC1L1) protein plays a central role in the intestinal cholesterol absorption and is the target of a drug, ezetimibe, which inhibits NPC1L1 to reduce cholesterol absorption. Here, we present cryo-electron microscopy structures of human NPC1L1 in apo state, cholesterol-enriche …