Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16.

2011年7月13日 · Recent studies have uncovered unexpected functions of NOD2 in innate immune responses such as induction of type I interferon and facilitation of autophagy; moreover, they have disclosed extensive...

NOD2 （Nucleotide-binding oligomerization domain 2）也被称为NLRC2，属于NLR家族，是革兰氏阳性和革兰氏阴性细菌的肽聚糖（PGN）衍生的细胞内 模式识别受体 （PRRs）。 NOD2由多种细胞类型表达，包括造血细胞（如T细胞、B细胞、巨噬细胞、树突状细胞和肥大细胞）和非造血细胞（如 潘氏细胞 、干细胞、杯状细胞和肠细胞），在胞浆中处于一种抑制的单体状态，配体识别时激活其构象发生变化，进而招募 丝氨酸 /苏氨酸蛋白激酶2（RIPK2）激活IKK复合物 …

The NOD2 gene (previously known as CARD15) provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as bacteria and viruses.

The nucleotide-binding oligomerization domain (NOD) proteins, NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce pro-inflammatory and anti-microbial ...

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response.

2024年12月25日 · NOD2 (Nucleotide Binding Oligomerization Domain Containing 2) is a Protein Coding gene. Diseases associated with NOD2 include Blau Syndrome and Inflammatory Bowel Disease 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

2021年4月27日 · NOD2是一种胞内受体，可识别分子胞壁二肽 (MDP)——细菌细胞壁中普遍存在的成分。 在NOD2被描述为克罗恩病的风险基因之前，NOD2的功能在 免疫 细胞中得到了最好的理解，它有助于免疫防御的固有分支。 这些细胞中NOD2的激活导致了称为细胞因子的炎症分子的表达，而异常强烈的炎症反应可以介导克罗恩病的肠道损伤。 因此，人们可能会认为，被称为功能缺失突变的NOD2突变不会产生功能完整的编码蛋白，可以 预防 克罗恩病。 然而，这种NOD2 …

它通过识别源自它们的胞壁酰二肽 (MDP) 并激活 NFKB 蛋白，在对细胞内细菌脂多糖 (LPS) 的免疫反应中发挥作用。 该基因的突变与克罗恩病和布劳综合征有关。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2014 年 6 月] This gene is a member of the NOD1 /Apaf-1 family and encodes a protein with two Caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs).

NOD2是一种胞内受体 (图1)，可以识别分子胞壁二肽 (MDP)——细菌细胞壁中普遍存在的成分。 细胞中NOD2的激活导致了称为细胞因子的炎症分子的表达，而异常强烈的炎症反应可以介导克罗恩病的肠道损伤。 因此，人们可能会认为，被称为功能缺失突变的NOD2突变，不会产生功能完整的编码蛋白，可以保护人们免受克罗恩病的侵袭。 然而，NOD2的这种功能缺失突变被确定为该疾病的危险因素。 因此，随后的研究转向肠道内NOD2生物学的不同方面，研究功能性NOD2如 …