NLRP1 encodes NACHT, LRR, FIIND, CARD domain and PYD domains-containing protein 1 in humans. [5] [6] [7] NLRP1 was the first protein shown to form an inflammasome. [8] NLRP1 is expressed by a variety of cell types, which are predominantly epithelial or hematopoietic.

NLRP1是NLR家族中比较异类的存在，其含有未知功能的FIIND（function-to-find domain）结构域，且其可激活Caspase位于蛋白C端的CARD（caspase activation and recruitment domain）结构域。 既往文献已发现NLRP1可经炭疽杆菌（Bacillus anthracis）的致死因子LF（lethal factor）自身水解后发生活化 【2-4】，但该活化机制仍不清楚。

慕尼黑工业大学的Veit Hornung课题组长期关注固有免疫中病原识别受体的功能，日前在Science发表题为 Human NLRP1 is a sensor for double-stranded RNA 的研究，发现皮肤组织内的NLRP1是RNA病毒感受器，PYD识别dsRNA后通过NACHT水解ATP实现活化，依赖ASC和Caspase-1完成 …

2023年12月16日 · This review focuses on recent studies identifying new human-specific NLRP1 mechanisms of activation of, gain-of-function human variants and disease, its role in responding to cellular stress, and...

已发现的炎性小体主要有5种，即 nlrp1炎性小体、nlrp3炎性小体、nlrc4炎性 小体 、 ipaf炎性小体和aim2炎性小体。 已知发现的炎性小体一般均含有凋亡相关微粒蛋白（ apoptosis -associated speck-like protein containing CARD,， ASC ）、 caspase 蛋白酶以及一种NOD样受 …

2024年12月25日 · NLRP1 (NLR Family Pyrin Domain Containing 1) is a Protein Coding gene. Diseases associated with NLRP1 include Respiratory Papillomatosis, Juvenile Recurrent, Congenital and Autoinflammation With Arthritis And Dyskeratosis. Among its related pathways are Innate Immune System and Inflammasomes.

2023年9月13日 · Here we identify ubiquitously expressed endogenous thioredoxin (TRX) as a binder of NLRP1 and a suppressor of the NLRP1 inflammasome. The cryo-electron microscopy structure of human NLRP1...

2022年7月6日 · NLRP1是NOD样受体家族中第一个被发现可以与ASC和caspase1形成复合体的蛋白，NLRP1 FIIND结构域可自发部分水解，产生NLRP1NT和NLRP1CT两条多肽链。 其中，NLRP1CT具有形成炎症小体的活性，NLRP1CT能够与NLRP1NT及未被切割的全长NLRP1FL形成自抑制体，抑制其自身的活性。 目前普遍认为NLRP1炎症小体会通过经典的NLRP1NT功能性降解（Functional degradation）激活。

We discuss a newly proposed 'functional degradation' mechanism that explains activation and assembly of NLRP1 into an oligomeric complex called an inflammasome. We also discuss how NLRP1 is activated by non-pathogen-associated triggers such as the anti-cancer drug Val-boroPro, or by human disease-associated mutations.

2019年3月14日 · Proteases such as anthrax lethal factor can activate an inflammasome known as NLRP1B, but the mechanism for this activation has been unclear. Chui et al. used genome-wide knockout screens to show that proteolysis of NLRP1B by lethal factor induces proteasomal degradation of the amino-terminal domains of NLRP1B and eventual cell death.