NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. [5][6] The NLRC4 protein is highly conserved across mammalian species. It bears homology to the C. elegans Ced4 protein.

The NLRC4 inflammasomopathies are caused by gain-of-function mutations in the gene encoding the innate immune protein NLRC4. Mutant NLRC4 promotes spontaneous formation of the NLRC4 inflammasome, production of IL1 family cytokines …

In this review article, we provide an updated overview of NLRC4 inflammasomes, describing their composition, activation mechanisms and roles in both microbial infections and other disease conditions. Keywords: NLRC4, inflammasome, autoimmune disease, cancer, PANoptosis.

2021年11月30日 · The NLRC4 inflammasome, a member of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, amplifies inflammation by facilitating the processing of caspase-1, interleukin...

In this review, we endeavor to highlight recent breakthroughs related to NLRC4 inflammasome structure and activation, important in vivo work in infection and systemic inflammation, and the characterization of a spectrum of human NLRC4-associated autoinflammatory diseases.

2024年12月25日 · NLRC4 (NLR Family CARD Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRC4 include Familial Cold Autoinflammatory Syndrome 4 and Autoinflammation With Infantile Enterocolitis.

In this review we give an overview of the NAIP/NLRC4 activation mechanism as well as the described roles of this inflammasome, with a focus on in vivo infection and pathology.

2024年6月3日 · Epithelial human NLRC4 promotes patient survival and is associated to Type-I Interferon signaling and immune infiltration in cancer. Higher vertebrates have developed innate protective mechanisms that can detect stress-induced …

2024年1月4日 · Here we identify Bacillus thailandensis type III secretion system needle protein (Needle) as a potent trigger of the human NLR family apoptosis inhibitory protein (NAIP)/NLRC4 inflammasome...

2011年9月14日 · Genetic analysis of Chromobacterium violaceum infection revealed that the TTSS needle protein CprI can stimulate NLRC4 inflammasome activation in human macrophages.