NIPBL - Wikipedia
Nipped-B-like protein (NIPBL), also known as SCC2 or delangin is a protein that in humans is encoded by the NIPBL gene. [5] NIPBL is required for the association of cohesin with DNA …
NIPBL Gene - GeneCards | NIPBL Protein | NIPBL Antibody
2024年12月25日 · NIPBL (NIPBL Cohesin Loading Factor) is a Protein Coding gene. Diseases associated with NIPBL include Cornelia De Lange Syndrome 1 and Cornelia De Lange …
Science | 于洪涛/白晓辰组合作报道人类粘连蛋白三维结构 - 知乎
为了克服粘连蛋白构象高度柔性的问题，研究人员对复合物样品进行了系统性地尝试和优化，最终获得稳定构象的粘连蛋白，NIPBL与72个碱基对双链DNA复合物的电镜结构。 粘连蛋 …
【Science论文拆解】人黏连蛋白-NIPBL-DNA复合物的冷冻电镜结 …
作者分辨率为4.0 Å下使用3D重组技术获得人黏连蛋白-NIPBL-DNA复合物，能够借助单个亚基的晶体结构建立几乎完整的模型对复合物的核心（包括NIPBLC， RAD21 和SMC1-SMC3 …
Different NIPBL requirements of cohesin-STAG1 and cohesin …
2023年3月10日 · Here we have examined the effect of reducing NIPBL levels on the behavior of the two cohesin variants carrying STAG1 or STAG2 by combining a flow cytometry assay to …
Roles of NIPBL in maintenance of genome stability - PubMed
A cohesin-loading factor (NIPBL) is one of important regulatory factors in the maintenance of 3D genome organization and function, by interacting with a large number of factors, e.g. cohesion, …
NIPBL
2018年1月18日 · We demonstrate that NIPBL haploinsufficiency leads to upregulation of gene sets identified in functions related to nucleosome, chromatin assembly, RNA modification and …
长达十年的科学争端终解决！两篇Science论文揭示人黏连蛋白通过 …
这些结果表明黏连蛋白-nipbl复合物是一种由atp驱动的能够进行dna环挤压的分子马达。 总之，这两项新的研究表明与黏连蛋白调节姐妹染色单体黏连在一起的方式不同，这种蛋白在环挤压过 …
NIPBL and cohesin: new take on a classic tale - Cell Press
2023年4月14日 · Here, we discuss recent research addressing how NIPBL modulates cohesin activities and how its mutation causes a developmental disorder, Cornelia de Lange Syndrome …
NIPBL gene - MedlinePlus
The NIPBL gene provides instructions for making a protein called delangin, which plays an important role in human development. Learn about this gene and related health conditions.
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