Myosin light chain - Wikipedia
A myosin light chain is a light chain (small polypeptide subunit) of myosin. [1] Myosin light chains were discovered by Chinese biochemist Cao Tianqin (Tien-chin Tsao) when he was a graduate student at the University of Cambridge in England.
Myosin Light Chain - an overview | ScienceDirect Topics
Myosin Light Chains are regulatory and essential proteins that belong to the EF-hand superfamily. They interact with the head-rod junction of myosin molecules and may play a role in determining the speed and force of actomyosin sliding.
Heavy and light roles: myosin in the morphogenesis of the heart
The myosin light-chain (MLC) proteins are also classed into two groups, the essential and regulatory light chains. This review will provide an overview of the roles the myosin proteins play in the developing heart and their potential to give rise to CHDs.
Regulation of myosin light-chain phosphorylation and its roles in ...
2021年10月6日 · Vascular tone is regulated by several factors, including rheological, hormonal, and neuronal stimuli, and phosphorylation of the myosin regulatory light chain (RLC) is a major intracellular...
Myosin Light Chain - an overview | ScienceDirect Topics
Myosin is a hexameric protein (MW = 480 kDa) comprising two heavy chains and four light chains. At the rod-shaped carboxyl terminus end of the myosin molecule, the two heavy chains (MW = 200 kDa) dimerize into a 200-nm alpha-helical tail.
Four Things to Know about Myosin Light Chains as Reporters for ...
Both myosin light chains play at least two important roles in the function of myosin-2. First, they are a structurally important part of the myosin holoenzyme since they bind to and stabilize an elongated helical segment of the heavy chain.
Insights into myosin regulatory and essential light chains: a focus …
Specifically, we focus on the involvement of myosin regulatory (RLC) and essential (ELC) light chains in striated muscle development, isoform appearance and their function in normal and diseased muscle.
Functions of Myosin Light Chain-2 (MYL2) In Cardiac Muscle and …
Myosin light chain-2 (MYL2, also called MLC-2) is an ∼19 kDa sarcomeric protein that belongs to the EF-hand calcium binding protein superfamily and exists as three major isoforms encoded by three distinct genes in mammalian striated muscle.
Myosin Light Chain - an overview | ScienceDirect Topics
The light chain components of myosin (myosin light chain 1; MLC 1 and light chain 2, MLC2) are well positioned to have a role in controlling cross-bridge function. MLC1 is also known as the essential light chain (ELC) and MLC2 is also known at …
Actin, Myosin, and Cell Movement - The Cell - NCBI Bookshelf
The myosin II molecule consists of two heavy chains and two pairs of light chains (called the essential and regulatory light chains). The heavy chains have globular head regions and long α-helical tails, which coil around each other (more...)