2024年12月25日 · MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I) is a Protein Coding gene. Diseases associated with MT-CO1 include Rare Mitochondrial Non-Syndromic Sensorineural Deafness and Acquired Idiopathic Sideroblastic Anemia. Among its related pathways are Gene expression (Transcription) and Cellular responses to stimuli.

Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation.

2025年2月8日 · Molecular characterization and haplotypes of hydatid cyst isolates collected from humans and ruminants in Setif Province (northeast of Algeria) based on mitochondrial cytochrome C oxidase subunit 1 (mt-CO1) gene sequences.

Our study results suggest that lymphoid mitochondrial hyperfunction at organ level may be an important intrinsic pathogenesis in systemic lupus erythematosus activity, which may affect mitochondrial dysfunction in non-immune organs. Keywords: Cytochrome C oxidase subunits 1, malondialdehyde, oxidative stress, systemic lupus erythematosus.

2025年2月8日 · Low aortic mitochondria-encoded COX1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher M1 macrophages and oxidized LDL. Caloric restriction increased COX1 and reduced plaque area and oxidized LDL.

A novel heteroplasmic mutation was identified in MTCO1, m.7402delC, causing frameshift and a premature termination codon in a mitochondrial encephalomyopathy patient with cytochrome c oxidase deficiency. A novel m.6307A>G mutation in the mitochondrial COXI gene in asthenozoospermic infertile men.

Somatic mutations within mitochondrial DNA (mtDNA) encoded cytochrome c oxidase subunit I (MT-CO1 or MT-COI) are frequent in various cancer types. In addition, perturbation from orchestrated expression of mitochondrial DNA encoded genes is also associated with complex disorders, including cancer.

2015年4月1日 · Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity). Search… Belongs to the heme-copper respiratory oxidase family. Search…

有助于细胞色素-c 氧化酶活性。 预测参与电子传输耦合质子传输和线粒体电子传输，细胞色素 c 到氧气。 线粒体呼吸链复合物 III 和线粒体呼吸链复合物 IV 的一部分。 [由基因组资源联盟提供，2022 年 4 月] Contributes to cytochrome-c oxidase activity. Predicted to be involved in electron transport coupled proton transport and mitochondrial electron transport, cytochrome c to oxygen.

2023年8月28日 · Encoded in the mitochondrial DNA, MT-CO1 catalyses the reduction of oxygen to water. COX1, a homologue of MT-CO1, has been related to longevity in the filamentous fungus Podospora anserina [207]. Mutations in the human MT-CO1 gene have been associated with several diseases, including neurodegenerative diseases [751].